Mendelian randomization of autoimmune hepatitis and cardiovascular diseases.

Feng Tang, Tian Jun Zhao, Pei Wen Dong, Kai Di Sun, Xiao Bin Sun, Qiong Wang

Abstract read

In one paragraph

Article in American heart journal plus : cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Feng TangDepartment of Gastroenterology, The Affiliated Hospital of Southwest Jiao tong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.

Tian Jun ZhaoDepartment of Cardiology, The Affiliated Hospital of Southwest Jiao tong University, The Third People's Hospital of Chengdu, Cardiovascular Disease Research Institute of Chengdu, Chengdu, 610031, China.

Pei Wen DongDepartment of Gastroenterology, The Affiliated Hospital of Southwest Jiao tong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.

Kai Di SunDepartment of Gastroenterology, The Affiliated Hospital of Southwest Jiao tong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.

Xiao Bin SunDepartment of Gastroenterology, The Affiliated Hospital of Southwest Jiao tong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.

Qiong WangDepartment of Gastroenterology, The Affiliated Hospital of Southwest Jiao tong University, The Third People's Hospital of Chengdu, Chengdu, 610031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have shown that autoimmune hepatitis (AIH) is associated with cardiovascular diseases (CVD), but the potential causal relationship between genetic susceptibility to AIH and CVD risk is unknown. This study systematically investigated the potential association between genetically determined AIH and the risk of CVD. The analysis was conducted by genome-wide association studies (GWAS), considering AIH as the exposure and cardiovascular disease as the endpoint. Mendelian randomization (MR) analysis was performed using inverse variance weighting (IVW) as the primary method. Additionally, a series of pleiotropy, heterogeneity test and sensitivity analyses were conducted to verify the reliability of the results.MR analysis showed that genetic susceptibility to AIH was associated with a higher risk of atrial fibrillation [OR = 1.01, 95 % CI (1.00-1.02),

Indexed as

Autoimmune hepatitisCardiovascular diseaseCausalityGenome-wide association studiesMendelian randomization

Identifiers

PMID41103357

DOI10.1016/j.ahjo.2025.100627

PMCPMC12524559

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.