ArticleClinical ophthalmology (Auckland, N.Z.)2025
The Association Between the Retinal Sequelae of Myopia and Glaucoma in a Global Cohort.
Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Artificial intelligence assisted quantitative analysis of fundus structural and vascular alterations reveals fundus tessellation as a robust biomarker of myopia severity.Frontiers in cell and developmental biology · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Purpose: Discerning glaucoma in myopic eyes with tilted optic nerve discs is challenging given the atypical appearance and segmentation on optical coherence tomography. This study aims to determine the association between retinal sequelae of myopia and primary open-angle glaucoma (POAG). We hypothesize that retinal sequelae of myopia may aid in identifying high-risk glaucoma patients. Methods: An aggregated electronic health records research network was used to retrospectively identify 929,142 myopic patients. We evaluated the association of POAG with retinal sequelae of myopia, including choroidal neovascularization (CNV), myopic macular degeneration (MMD), foveoschisis, macular hole (MH), rhegmatogenous retinal detachment (RRD), and foveal retinal detachment (FRD). Logistic regressions estimated odds ratios (adjusted for age, sex, race, and ethnicity). Cox models estimated hazard ratios (additionally adjusted for pseudophakia). Results: FRD exhibited the strongest association with POAG (AOR: 5.82; 95% CI: 3.44-9.85), followed by foveoschisis (AOR: 3.10; 95% CI: 1.84-5.21) and MMD (AOR: 2.87; 95% CI: 2.19-3.75). Severe subtypes of POAG were also more highly associated with each retinal sequela than moderate and milder severity subtypes. Additionally, patients with each retinal sequela experienced a significantly faster progression from glaucoma suspect to POAG than those without these sequelae. Kaplan-Meier curves and adjusted Cox regression models suggested a faster progression from glaucoma suspect to POAG in those with foveoschisis (HR: 5.33; 95% CI: 2.21-12.85; p<0.005), CNV (HR: 1.73; 95% CI: 1.12-2.67; p=0.01), MMD (HR: 2.74; 95% CI: 1.47-5.10; p<0.005), MH (HR: 1.73; 95% CI: 1.29-2.31; p<0.005), and RRD (HR: 1.54; 95% CI: 1.28-1.86; p<0.005), whereas FRD was not significantly associated with glaucoma progression (HR: 1.28; 95% CI: 0.18-9.10; p=0.8). Conclusion: The retinal sequelae of myopia are associated with the presence and progression of primary open-angle glaucoma. The presence of the retinal sequelae of myopia should cue ophthalmologists to refer such patients for glaucoma evaluation to encourage earlier detection and more targeted management.
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