Evidence map›Paper›PMID 41103262›Full record

ArticleAnatomy & cell biology2025

Rhubarb water extract as a promising gastroprotective agent in Tamoxifen induced parietal cell damage in female rats: a histological study.

Rahma Kamal-Al-Din Abou El-Nour, Rana Maged Yakout, Ehab Refaat Ibrahim, Mostafa Hassan Baky, Samaa Samir Kamar

Abstract read
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In one paragraph

Article in Anatomy & cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rahma Kamal-Al-Din Abou El-NourDepartment of Histology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt.ORCID https://orcid.org/0000-0002-2690-760X
Rana Maged YakoutDepartment of Histology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt.ORCID https://orcid.org/0009-0007-8495-8003
Ehab Refaat IbrahimDepartment of Histology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt.ORCID https://orcid.org/0009-0006-9900-7764
Mostafa Hassan BakyDepartment of Pharmacognosy, College of Pharmacy, Egyptian Russian University, Badr City, Egypt.ORCID https://orcid.org/0000-0002-8597-7974
Samaa Samir KamarDepartment of Histology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt.ORCID https://orcid.org/0000-0002-9040-584X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tamoxifen (TAM) is one of the most used drugs in the prevention and treatment of breast cancer. A set of common side effects was recorded associating its prolonged clinical use that ranges 3-10 years. This study aimed to investigate TAM-induced parietal cells (PCs) injury in rats and the possible protective effect of rhubarb (Rh) water extract (WE). Twenty-four adult female rats were distributed as: control group, TAM-group (3 mg/kg/day TAM for 4-weeks) and TAM+Rh-group (combined 3 mg/kg/day TAM and 20 mg/kg Rh-WE for 4-weeks). Blood sample before euthanizing rats was tested for vitamin-B12. PCs in stomach fundus were examined using histological and transmission electron microscopic studies, besides immunohistochemistry for Caspase-3, proliferating cell nuclear antigen (PCNA) and hydrogen potassium (H

Indexed as

Caspase-3Electron microscopyGastric parietal cellsHydrogen potassium ATPaseTamoxifen

Identifiers

PMID41103262
PMCPMC12719113

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.