Evidence map›Paper›PMID 41103093›Full record

ArticleAnnals of clinical and translational neurology2026

Impact of Stress-Induced Hyperglycemia on In-Hospital Medical Complications in Patients With Acute Stroke: From a Large-Scale Nationwide Longitudinal Registry.

Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao

Abstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xintong SongDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0009-0003-9687-2937
Yi JuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hongqiu GuChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-1608-1856
Zhikai ZhuChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zixiao LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-4713-5418
Qian ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xingquan ZhaoDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-8345-5147

Funding

Beijing Scholar 097National Health Commission of the People's Republic of China W2024SNKT23National Key Research and Development Program of China 2022YFC3501100National Key Research and Development Program of China 2022YFC3501102National Natural Science Foundation of China GrantNo.82371302Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0522200Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0522203
6 · The paper itself

Abstract

aimsThis study aimed to explore the relationship between stress-induced hyperglycemia (SIH) and in-hospital medical complications in patients with acute stroke.

methodsWe enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort. The stress hyperglycemia ratio (SHR) was defined as the ratio of fasting blood glucose to glycosylated hemoglobin. The primary outcomes were in-hospital medical complications, including urinary tract infection (UTI), pneumonia, deep venous thrombosis (DVT), pulmonary embolism (PE), gastrointestinal bleeding (GIB), and pressure sores. Logistic regression analyses were performed to assess the association between the SHR and in-hospital medical complications.

resultsIn total, 104,873 (12.11%) patients with acute stroke experienced at least one in-hospital medical complication. The most frequently observed complications were pneumonia (9.84%), UTI (1.29%), and GIB (1.06%). Both univariate and multivariate logistic regression analyses showed that a higher SHR was associated with a higher prevalence of pneumonia, UTI, GIB, and pressure sores (P for trend < 0.01). After adjusting for potential confounders, a higher SHR was associated with a reduced risk of PE (P for trend < 0.05), whereas no significant association was found between SHR and DVT. In the subgroup analysis, a significant association between elevated SHR and the occurrence of in-hospital complications was further confirmed.

conclusionsSIH is significantly associated with in-hospital medical complications, particularly pneumonia, UTI, GIB, and pressure sores, in patients with acute stroke.

Indexed as

Gastrointestinal HemorrhageHyperglycemiaPneumoniaPressure UlcerStress, PsychologicalStrokeUrinary Tract InfectionsAgedAged, 80 and overBlood GlucoseChinaFemaleGlycated HemoglobinHospitalizationHumansLongitudinal StudiesBlood GlucoseGlycated Hemoglobinacute strokefasting blood glucosemedical complicationsstress hyperglycemia

Identifiers

PMID41103093
PMCPMC12968442

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.