ArticleJournal of dental research2026
Mir-27 Promotes Periodontal Regeneration via Osteogenesis/Angiogenesis.
Article in Journal of dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Application of Temporally Controlled Release Systems in Periodontal Tissue Regeneration: From Material Design to Therapeutic Strategies.Pharmaceutics · 2026Review
- The Role of Wnt Signaling in Age-Related Alveolar Bone Loss and Regeneration.Journal of periodontal research · 2026Review
- MicroRNAs in periodontal disease: from pathogenic mechanisms and RANKL/OPG regulation to nanoparticle delivery and personalized medicine.Frontiers in immunology · 2026Review
- MicroRNA-driven periodontal immune homeostasis and tissue regeneration: from regulatory networks to engineering translation.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The interplay between osteogenesis and angiogenesis is an important prerequisite for successful bone regeneration as it provides capillary supply to the initial bone lamellae involved in skeletogenesis. The Wnt signaling pathway is one of the key signaling pathways promoting both osteogenesis and angiogenesis. In the present study, we evaluated the regenerative potential of microRNA-27 (miR-27) by delivering miR-27 mimic via lipid nanoparticles (LNPs) to enhance periodontal tissue repair through the targeted modulation of Secreted Frizzled-Related Protein 1 (SFRP1). Our study demonstrated that inflammatory conditions inhibit the expression and function of miR-27 in a periodontitis model. miR-27 treatment significantly upregulated key modulators of periodontal regeneration, including osteogenic markers (ALP, RUNX2, and COL1) and angiogenic factors (CD31, CD34, and VEGF). This treatment also resulted in increased alkaline phosphatase activity and enhanced mineral deposition, alongside improved spheroid sprouting and tube formation in Matrigel cultures. LNPs were applied to optimize miR-27 delivery for efficient transfection. In vivo implantation revealed that miR-27 accelerated extracellular matrix remodeling in subcutaneous implants, induced a 6-fold increase in neovascularization, and significantly enhanced periodontal tissue formation and bone regeneration, as evidenced by a 43.9% reduction in the distance between the alveolar bone ridge and the cementoenamel junction. Mechanistically, miR-27 promoted osteogenic and angiogenic responses by suppressing SFRP1, a known Wnt signaling inhibitor and validated target of miR-27, thereby activating the Wnt pathway. Together, these studies demonstrate that miR-27 mimic functioned as a bioactive molecule promoting periodontal tissue regeneration through angiogenesis coinciding with osteogenesis. Our study also suggests that the miR-27-LNPs/scaffold combination is an exciting novel agent for the treatment of periodontal disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.