Evidence map›Paper›PMID 41102972›Full record

ArticleJournal of dental research2026

BMP/WNT-Dependent Mechanisms of Junctional Epithelium Turnover.

B Liu, F Cao, S Zheng, X Yuan, N Mandalapu, J S Park, M O Sugihara, Y Mishina, J A Helms

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

B LiuDepartment of Surgery, Stanford University School of Medicine, Stanford CA, USA.
F CaoDepartment of Surgery, Stanford University School of Medicine, Stanford CA, USA.
S ZhengDepartment of Surgery, Stanford University School of Medicine, Stanford CA, USA.
X YuanDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, Indiana University, IN, USA.ORCID 0000-0002-8063-9431
N MandalapuDepartment of Surgery, Stanford University School of Medicine, Stanford CA, USA.
J S ParkDepartment of Surgery, Stanford University School of Medicine, Stanford CA, USA.
M O SugiharaDepartment of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, MI, USA.
Y MishinaDepartment of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, MI, USA.
J A HelmsDepartment of Surgery, Stanford University School of Medicine, Stanford CA, USA.ORCID 0000-0002-0463-396X

Funding

Molecular mechanisms mediating the soft tissue attachment to teethR01DE031270 · NIDCR · STANFORD UNIVERSITY · PI Jill A Helms · 2023 to 2026
$2.9M
NIDCR NIH HHS R01 DE031270
6 · The paper itself

Abstract

As a first line of defense against periodontal diseases, the junctional epithelium must establish a firm attachment to the tooth surface while allowing new cells arising from the stem cell niche to migrate through the tissue. How these static and dynamic cell behaviors are coordinated in the junctional epithelium is not clear; we hypothesize it involves the epithelial-to-mesenchymal transition (EMT). An intact junctional epithelium was interrogated via quantitative immunohistochemistry for molecular markers of EMT; since EMT is also critical for tissue repair, the junctional epithelium was also interrogated at multiple time points after ligature-induced periodontitis. These analyses revealed that junctional epithelial cells transition from a polarized, cell-adherent phenotype to one in which cytoskeletal remodeling and increased motility occur. To gain insights into molecular mechanisms regulating EMT, we used a genetic system to delete the BMP type I receptor (BMPR1a) in postnatal mice. Within 7 d of BMPR1a inactivation, multiple EMT signaling pathways including Wnt/β-catenin, transforming growth factor-β, and Notch signaling were upregulated in the junctional epithelium. The mutant junctional epithelium exhibited extensive EMT accompanied by downregulation of the hemidesmosomal proteins Laminin5, plectin, and β4 integrin. Together, these findings demonstrate that normal junctional epithelium turnover used EMT and that this physiological process is controlled in part by WNT/BMP signaling.

Indexed as

Bone Morphogenetic ProteinsEpithelial AttachmentEpithelial-Mesenchymal TransitionWnt Signaling PathwayAnimalsbeta CateninBone Morphogenetic Protein Receptors, Type ICell AdhesionCell MovementEpithelial CellsIntegrin beta4MiceSignal TransductionTransforming Growth Factor betabeta CateninBmpr1a protein, mouseBone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsIntegrin beta4Transforming Growth Factor betacell plasticityepithelial attachmentepithelial–mesenchymal transitionhemidesmosomehomeostasisstem cell niche

Identifiers

PMID41102972
PMCPMC13331256

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.