ArticleMacromolecular rapid communications2026
Poly(2-Oxazoline)-Based Polyphotoacids: Synthesis, Solution Behavior, and Cellular Uptake of Multi-Responsive Intracellular Transporters.
Article in Macromolecular rapid communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Poly(2-Oxazoline)-Based Polyphotoacids: Synthesis, Solution Behavior, and Cellular Uptake of Multi-Responsive Intracellular Transporters.Macromolecular rapid communications · 2026Article
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Authors and funding
8 authors.
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Abstract
This work describes the first polymeric photoacids based on poly(2-oxazoline)s. The presence of 1-hydroxypyrene units-a photoacid that can increase its acidity upon blue light irradiation through excited-state proton transfer-allows remote control over material polarity and charge. A set of multi-stimuli-responsive polymers was obtained via partial hydrolysis of poly(2-ethyl-2-oxazoline) precursors, followed by functionalization with 6/8-acetoxypyrene-1-sulphonyl chloride. By varying the reagent ratio, complete or partial functionalization of hydrolyzed units can be achieved; in the latter case some remaining polyethyleneimine (PEI) groups can also be realized. Conducted cytotoxicity studies show high viability of selected cell lines, which serves as a first reported confirmation of biocompatibility of polyphotoacids. This was further confirmed via cellular uptake experiments, where the synthesized copolymers show no cell damage after 24 h of incubation. Apart from that, the polyphotoacid with the highest hydroxypyrene content and remaining PEI-units shows the fastest uptake. The same terpolymer also shows a high capacity for hydrophobic drug encapsulation. The obtained results support the prospect of polyphotoacids as materials in the context of intracellular transport.
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