Evidence map›Paper›PMID 41102922›Full record

ArticleNeurogastroenterology and motility2026

Socio-Economic Determinants and Regional Prevalence of Disorders of Gut-Brain Interaction in the Netherlands: Results From the Rome Foundation Global Epidemiology Study.

F Veldman, F Innocenti, M A Benninga, A D Sperber, O S Palsson, S I Bangdiwala, D Keszthelyi

Abstract read
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In one paragraph

Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

F VeldmanDepartment of Gastroenterology-Hepatology, NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.ORCID https://orcid.org/0009-0003-3925-3523
F InnocentiDepartment of Methodology and Statistics, Faculty of Health Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0001-6113-8992
M A BenningaDepartment of Pediatric Gastroenterology, Amsterdam Gastroenterology, Endocrinology, and Metabolism Research Institute, Amsterdam Reproduction and Development Research Institute, Emma Children's Hospital, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-9406-9188
A D SperberFaculty of Health Sciences, Ben-Gurion University of the Negev, Be'er Sheva, Israel.ORCID https://orcid.org/0000-0002-7634-3689
O S PalssonCenter for Functional GI & Motility Disorders, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0001-5295-2183
S I BangdiwalaDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0002-3111-0689
D KeszthelyiDepartment of Gastroenterology-Hepatology, NUTRIM Research Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0001-9856-9980

Funding

Dutch Foundation for GastroenterologyHorizon 2020Horizon EuropeRome FoundationUnited European GastroenterologyZonMw
6 · The paper itself

Abstract

backgroundDisorders of gut-brain interaction (DGBI) impose significant burdens worldwide, yet reliable regional prevalence estimates are lacking, limiting insight into potential geographic variation. Socio-economic status (SES) may contribute but remains underexplored.

methodsData were obtained from the Dutch cohort of the Rome Foundation Global Epidemiology Study, including the Rome IV Adult Diagnostic Questionnaire, sociodemographic items, and SES indicators. The Netherlands was divided into three regions (Region 1: South; Region 2: West; Region 3: North-East). Regional prevalence was calculated for any DGBI, groups, and subtypes. Associations with SES were examined using logistic regression. KEY

results2008 participants (50% female; age: 48 years [IQR: 31]; BMI: 25.25 kg/m CONCLUSION AND INFERENCES: DGBI affect nearly one-third of adults in the Netherlands, with no regional variation in prevalence. Putative risk factors include limited/no healthcare access and unemployment, supporting consideration of socioeconomic determinants in DGBI care, although further research is warranted.

Indexed as

Brain-Gut AxisGastrointestinal DiseasesAdultCohort StudiesFemaleHumansMaleMiddle AgedNetherlandsPrevalenceSocial ClassSocioeconomic Factorsdisorders of gut‐brain interactionepidemiologyNetherlandsRome IV diagnostic criteriasocio‐economic factors

Identifiers

PMID41102922
PMCPMC12814999

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.