ArticleInternational journal of retina and vitreous2025
Aflibercept, ranibizumab, and bevacizumab for macular neovascularization secondary to age-related macular degeneration: a retrospective OCT-angiography study.
Article in International journal of retina and vitreous, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Preclinical evaluation of AL-001, a gene therapy for wet age-related macular degeneration.Frontiers in genetics · 2026Article
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7 authors.
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Abstract
backgroundIntravitreal aflibercept, ranibizumab, and bevacizumab represent the three most widely used anti-VEGF agents for the treatment of neovascular age-related macular degeneration (AMD). The objective of this study is to compare the loading phase effects of these three agents on the macular neovascularization (MNV) area and flow in treatment-naïve eyes affected by neovascular AMD, utilizing optical coherence tomography angiography (OCTA).
methodsEighty-four neovascular AMD eyes from eighty-four patients were included in this retrospective study. Twenty-five patients were treated with aflibercept, thirty-four with ranibizumab, and twenty-five with bevacizumab within the initial loading phase preceding a treat-and-extend regimen. All patients underwent a three-monthly injection loading phase and were evaluated at baseline and one month after the loading phase. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), MNV area, and MNV flow area were assessed. MNV parameters were measured using the device-integrated “Flow Area” tool and ImageJ software.
resultsAverage baseline BCVA and CRT were 0.60 ± 0.22 logMAR and 343 ± 46 μm, respectively, and did not differ between groups. All three anti-VEGF agents improved anatomical and functional parameters, with no statistically significant differences between treatment groups (p > 0.05). Aflibercept showed the most significant CRT reduction (88 μm; p < 0.01), while bevacizumab led to the highest BCVA gain (0.15 logMAR; p < 0.01). MNV area significantly decreased only in the bevacizumab group (0.26 mm2; p < 0.01), and flow area only in the ranibizumab group (0.23 mm2; p < 0.05). A strong positive correlation between MNV areas and flow areas was found at baseline (r > 0.8) and follow-up (r > 0.9).
conclusionsAflibercept, ranibizumab, and bevacizumab demonstrated similar efficacy in reducing MNV area and flow and improving visual and anatomical outcomes after a three-injection loading phase. OCTA-derived flow area measurement may be a valuable and easily accessible tool in monitoring early treatment response.
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