Evidence map›Paper›PMID 41102826›Full record

ArticleVeterinary research2025

PRRSV NSP5 orchestrates dual immune disruption by targeting NLRP3 and STING.

Xiangyu Huang, Xuyan Xiang, Xiaohan Jiang, Weiyu Qu, Yufei Zhang, Zhenchao Zhao, Minjie Li, Haiwei Wang, Xin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. PRRSV suppresses ER-phagy through Nsp2- and Nsp5-mediated degradation of FAM134B.Frontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiangyu HuangState Key Laboratory of Veterinary Public Health and Safety, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Xuyan XiangState Key Laboratory of Animal Disease Control, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Xiaohan JiangState Key Laboratory of Veterinary Public Health and Safety, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Weiyu QuState Key Laboratory of Veterinary Public Health and Safety, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Yufei ZhangState Key Laboratory of Veterinary Public Health and Safety, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Zhenchao ZhaoState Key Laboratory of Veterinary Public Health and Safety, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Minjie LiState Key Laboratory of Veterinary Public Health and Safety, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Haiwei WangState Key Laboratory of Animal Disease Control, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China. wanghaiwei@caas.cn.
Xin LiState Key Laboratory of Veterinary Public Health and Safety, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. xinli2021@cau.edu.cn.ORCID http://orcid.org/0000-0003-1636-8910

Funding

National Key Research & Development Program of China 2022YFD1800300National Natural Science Foundation of China 32373020
6 · The paper itself

Abstract

Inflammasomes and interferons are two critical defense mechanisms of innate immunity, and their imbalance is a key strategy employed by viruses to evade host immune surveillance. During porcine reproductive and respiratory syndrome virus (PRRSV) infection, an arteritis virus, a characteristic "high inflammation, low interferon" immune imbalance is observed. This study identifies PRRSV non-structural protein NSP5 as a central mediator of this immune imbalance. We demonstrate that NSP5 recruits NLRP3 to the endoplasmic reticulum (ER)-mitochondrial interface, triggering ER stress and Ca

Indexed as

Membrane ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusViral Nonstructural ProteinsAnimalsImmunity, InnateInflammasomesSwineInflammasomesMembrane ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinViral Nonstructural ProteinsIFN-INLRP3 inflammasomeNSP5PRRSVSTING

Identifiers

PMID41102826
PMCPMC12533338

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.