Observational studyThe journal of headache and pain2025
Impact of visceral pain on migraine symptoms in comorbid patients: a retrospective observational study.
Observational study in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The microgenderome in migraine: integrating sex hormones, microbial composition, and metabolic profiles into a sex-related framework.Frontiers in microbiology · 2026Review
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8 authors.
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Abstract
backgroundVisceral pain and migraine, especially at a high frequency/chronic, are frequent comorbidities, but little is known about their mutual influences. This study investigated if visceral pain-migraine comorbidity involves higher migraine pain and somatic hyperalgesia than migraine-only and if effective visceral pain treatment also improves migraine and hyperalgesia parameters.
methodsRetrospective analysis of 2,903 charts of migraine patients presenting at a Hospital Headache Center for a first visit over 3 years, + 1 follow-up year. Selected charts of female patients meeting inclusion criteria were: 117 migraine-only and 139 migraine + visceral pain, including 50 dysmenorrhea, 48 irritable bowel syndrome (IBS), 41 painful bladder syndrome/recurrent infectious cystitis (PBS/C). They were reviewed for migraine parameters: monthly attacks, symptomatic consumption and pain intensity, for visceral pain: painful menstrual cycles, IBS and bladder pain days, and for sensory parameters: muscle, subcutis and skin electrical pain thresholds, pressure pain thresholds at three sites (trapezius, deltoid and quadriceps), all routinely part of the visit. Migraine-only (M) and migraine + visceral pain (M + VP) patients were compared. In comorbid subgroups, all under the same migraine prophylaxis, the effects of visceral treatment, i.e., 21 hormonal/laser for endometriosis in primary/secondary dysmenorrhea, 25 dietary in IBS, 23 bladder instillations in PBS or antibiotics in infectious cystits, or no treatment were also reviewed on both migraine and visceral pain parameters over 6 months.
resultsMigraine + visceral pain vs. migraine-only patients had: higher number and intensity of migraine attacks and symptomatic consumption for migraine and lower pain thresholds in all somatic tissues (p < 0.0001). In comorbid patients, all migraine and sensory parameters improved after migraine prophylaxis (0.0001 < p < 0.002), but patients undergoing effective visceral treatment, i.e., decreased visceral episodes/days, presented a higher reduction of migraine attacks, symptomatic consumption and migraine intensity and a higher increase in pain thresholds than patients not undergoing visceral treatment (0.0001 < p < 0.04).
conclusionsVisceral pain comorbidity involves higher levels of migraine pain and somatic hyperalgesia than migraine-only. Treatment of the visceral condition vs. no treatment results in a better outcome of migraine and sensory parameters, suggesting that management of visceral pain should represent an integral part of the therapeutic regimen in comorbid migraine patients.
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