ArticleLipids in health and disease2025
Associations of obesity-related mammary intraductal secretions with inflammatory severity, immune dysregulation, and adverse prognosis in non-puerperal mastitis: a retrospective cohort study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Local Triamcinolone Injection versus Anti-Tuberculosis Triple Therapy for Non-Puerperal Mastitis: A Comparative Study.International journal of women's health · 2026Article
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8 authors.
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Abstract
purposeThis study aimed to evaluate the association between mammary intraductal secretions (IDS) and demographic characteristics, clinical manifestations, laboratory indicators and prognosis in patients with non-puerperal mastitis (NPM). PATIENTS AND
methodsA retrospective analysis of 340 NPM patients who underwent surgical treatment at the Department of Breast, Shuguang Hospital, between April 2020 and December 2021 was conducted. Based on intraoperative findings of IDS, patients were divided into two groups: the IDS group (with intraductal lipid-like secretions) and the non-IDS group (without intraductal lipid-like secretions). Demographic data, clinical features, laboratory parameters, and prognostic outcomes were systematically compared between the two groups.
resultsPatients with NPM and IDS had a significantly higher median age at disease onset (33 years vs. 32 years; P = 0.047) and body mass index (BMI) (24.0 kg/m
conclusionsThis study demonstrates that obesity-related IDS are significantly associated with increased systemic inflammation, immune dysregulation, and unfavorable prognostic outcomes in NPM. The identification of IDS provides valuable insight for risk stratification and supports the development of personalized management strategies. Overweight and obesity were identified as independent risk factors for IDS, highlighting weight control as a potential therapeutic approach. Future investigations should focus on elucidating the underlying mechanisms and exploring targeted therapeutic strategies to improve clinical outcomes.
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