ArticleEnvironmental health : a global access science source2025
Chlordecone exposure in women and time to pregnancy: the Timoun cohort study in Guadeloupe, French West Indies.
Article in Environmental health : a global access science source, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChlordecone is a persistent organochlorine insecticide that was widely used to control banana root borer in the French West Indies until 1993. Animal studies have reported an impact of chlordecone exposure on female fertility, but no data are available for humans. Here, we investigated the association between chlordecone exposure in women and time to pregnancy (TTP).
methodsWe included 668 pregnant women from the Timoun mother-child cohort study performed in Guadeloupe between 2004 and 2007. TTP was measured with a questionnaire at the inclusion visit. Chlordecone concentrations in maternal blood samples were determined at the time of delivery. A discrete-time Cox model was used to estimate fecundability odds ratios (fOR) and their 95% confidence intervals (95% CIs), with adjustment for potential confounders. Sensitivity analyses were performed by modifying the study population and censoring criteria.
resultsChlordecone was detected in 91% of the study population, with a median concentration of 0.3 µg/L (IQR: 0.1–0.7). The third and fourth quartiles of chlordecone exposure were associated with significantly lower fecundability (fORa [95% CI] = 0.76 [0.58, 0.99]; fORa [95% CI] = 0.72 [0.55, 0.95], respectively). A significant dose-dependent relationship was observed between chlordecone exposure and TTP (p-trend = 0.01). Similar results were observed in all sensitivity analyses except that for primiparous women.
conclusionOur study supports the hypothesis that chlordecone affects the fertility of women and is therefore a public health concern in widely contaminated areas, such as the French West Indies.
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