SynthesisBMC gastroenterology2025
Efficacy of hydration combined with rectal non-steroidal anti-inflammatory drugs (NSAIDs) versus NSAIDs alone for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Preventing Post-ERCP Pancreatitis: A Pragmatic Clinical Pathway from Periprocedural Prophylaxis to Early Postprocedural Triage.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThe most prevalent complication of endoscopic retrograde cholangiopancreatography (ERCP) is post-ERCP acute pancreatitis (PEP). Both hydration and rectal non-steroidal anti-inflammatory drugs (NSAIDs) can effectively prevent PEP; however, there is currently no consensus on whether combination therapy is more effective than either intervention alone.
methodsThe PubMed/Medline, Web of Science, Embase and Cochrane Library (last updated in October 2024) were systematically searched to identify and screen potentially eligible studies, from which relevant data were extracted, Review Manager 5.3 was used for meta-analysis to determine the preventive utility of hydration + rectal NSAIDs for PEP.
resultsFive studies comprising 1344 patients were included in the meta-analysis. Patients were divided into 2 groups (hydration + NSAIDs [n=654] and NSAIDs alone [n=690], a total of 107 patients experienced PEP (hydration + NSAIDs [n=40] and NSAIDs alone [n=67]). Results of meta-analysis revealed no significant difference in the incidence of PEP between patients receiving rectal NSAIDs + hydration versus rectal NSAIDs alone (odds ratio [OR] 0.57, 95% confidence interval [CI] 0.25-1.30; P = 0.18).
conclusionCompared with rectal NSAIDs alone, the combination of hydration and rectal NSAIDs does not appear to have a significant synergistic effect in the prevention of PEP. However, considering their distinct mechanisms of action and the observed reduction in PEP incidence with combined use, we believe that this approach still holds considerable clinical relevance. Further large-scale studies are needed to validate these findings.
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