Evidence map›Paper›PMID 41102609›Full record

ReviewThe Journal of infectious diseases2025

Polyclonal and Monoclonal Antibodies for the Treatment and Prevention of Influenza.

John H Beigel, David Oldach

Abstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John H BeigelNational Institute of Allergy and Infectious Diseases, Rockville, Maryland.ORCID 0000-0002-4879-4941
David OldachVisterra, Inc, Waltham, Massachusetts.

Funding

National Institute of Allergy and Infectious DiseasesNIH HHS
6 · The paper itself

Abstract

While at least 8 monoclonal and 3 polyclonal antibody products have been tested in clinical trials for the treatment of influenza, no products have been licensed, and most have stopped clinical development. The COVID-19 pandemic demonstrated that these approaches, especially monoclonal antibodies, may have unique potential in certain stages of disease and populations, especially in preventing severe disease in a population without preexisting immunity or in those with a limited capacity to mount an effective humoral immune response. This review summarizes past and ongoing efforts in using monoclonal and polyclonal antibodies for the treatment and prevention of influenza, focusing on products that have entered clinical trials and drawing lessons from COVID-19 to direct future efforts on these strategies.

Indexed as

Antibodies, MonoclonalAntibodies, ViralInfluenza, HumanClinical Trials as TopicCOVID-19HumansSARS-CoV-2Antibodies, MonoclonalAntibodies, ViralCR6261CR8020CT-P27FGI-101-1A6high titer immune globulinhigh titer immune plasmaMEDI8852MHAA4549ATCN-032VIR-2482VIS410

Identifiers

PMID41102609
PMCPMC12530947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.