Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Investigating fatigue in adults with neuroendocrine neoplasms using a biopsychosocial model.
Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03739827 (Natural History and Biospecimen Acquisition Study for Children and Adults With Rare Solid Tumors), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Natural History and Biospecimen Acquisition Study for Children and Adults With Rare Solid Tumors
Who cites it
1 citing paper in PubMed.
- Pain Predicts Next-Day Fatigue in Adolescents and Young Adults Receiving Maintenance Treatment for Acute Lymphoblastic Leukemia.Journal of adolescent and young adult oncology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeNeuroendocrine neoplasms (NEN) are rare but increasingly recognized malignancies. Fatigue is common among individuals with NEN, but factors associated with fatigue in this population are not well described. Understanding these factors is essential for optimizing supportive care and quality of life. This study aimed to investigate factors associated with fatigue in patients with NEN using a biopsychosocial model.
methodsParticipants enrolled on a rare tumor natural history study (NCT03739827) were included in this analysis if they had NEN, were ≥ 18 years old, and completed at least one evaluation of patient-reported outcome measures. Fatigue was assessed using the Patient-Reported Outcome Measurement Information System (PROMIS).
resultsSixty-four adult participants with NEN (mean age = 59 years; SD = 12.0) completed PROMIS measures. Over half (53%) had PROMIS Fatigue T-scores > 55, indicating fatigue, including 31% in the moderate-to-severe range. Fatigue was highly correlated with pain, functional status, and psychosocial factors including depression, anxiety, and emotional support. There were no significant differences in fatigue based on identified sociodemographic or disease-related factors, although a significant association between fatigue and serotonin, a neuroactive peptide secreted by some NENs, was found in a subset of patients.
conclusionFatigue is common in patients with NEN, with one-third having moderate to severe fatigue impacting daily functioning. Pain, anxiety, and depression were significantly associated with fatigue, suggesting that interventions targeting these symptoms also may improve fatigue in these patients. Further work is needed to investigate additional NEN-specific factors to optimize management of fatigue in individuals living with this long-term disease.
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