Evidence map›Paper›PMID 41102557›Full record

ArticleNature biomedical engineering2026

Inhibition of LARP4-mediated quiescence exit of naive CD4

Jian Zhou, Di Yang, Chao Han, Hui Dong, Shufeng Wang, Xiang Li, Jun Hu, Cui Wang, Jie Luo, Zhiyuan Wei and 22 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Jian Zhou *Institute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Di Yang *Institute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Chao Han *Institute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Hui Dong *Institute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Shufeng Wang *Institute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Xiang LiDepartments of Physics and Anatomy and Cell Biology, The George Washington University, Washington, DC, USA.ORCID http://orcid.org/0000-0002-8931-3681
Jun HuThe First Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Cui WangThe First Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Jie LuoThe First Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Zhiyuan WeiThe First Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Taiping LiuDepartment of Pathogenic Biology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.ORCID http://orcid.org/0000-0003-2261-1155
Shuai XuThe Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Chen XuInstitute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Yiwei ZhangInstitute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Xian WangDepartment of Immunology, Medical College of Qingdao University, Qingdao, People's Republic of China.
Yuanyu DengInstitute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Baiqing LiInstitute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Ruihan MaoInstitute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Mingyang ZhangThe Third Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Yi SunThe First Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Xinyuan ZhouInstitute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Lilin YeInstitute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Bing NiDepartment of Pathophysiology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Jun ZhuShanghai Introncure Biotechnology, Inc., Shanghai, People's Republic of China.
Juan LiDepartment of Medical Genetics, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Jingbo ZhangThe Second Affiliated Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Tingting ZhaoChongqing International Institute for Immunology, Chongqing, People's Republic of China.
Xiangmei ChenDepartment of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, National Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.ORCID http://orcid.org/0000-0001-8774-6021
Rong LinSanya People's Hospital, Sanya, China.
Yi ZhangChongqing International Institute for Immunology, Chongqing, People's Republic of China. zhangyi@iiicq.vip.ORCID http://orcid.org/0000-0003-1064-1867
Yuzhang WuInstitute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China. wuyuzhang@tmmu.edu.cn.ORCID http://orcid.org/0000-0002-5948-1596
Yi TianInstitute of Immunology, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China. tianyi@tmmu.edu.cn.ORCID http://orcid.org/0009-0009-2644-3321

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32141005National Natural Science Foundation of China (National Science Foundation of China) 32170887National Natural Science Foundation of China (National Science Foundation of China) 92269110
6 · The paper itself

Abstract

Naive T cells are maintained under a quiescent state, and their exit from quiescence is a hallmark of antigen stimulation. Here we identify the RNA binding protein La-related protein 4 (LARP4) as an important checkpoint regulator of quiescence exit in naive CD4

Indexed as

AutoantigensAutoimmune DiseasesCD4-Positive T-LymphocytesHypersensitivityRibonucleoproteinsAnimalsCell DifferentiationLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutPeptidesRNA StabilitySS-B AntigenAutoantigensPeptidesRibonucleoproteinsSS-B Antigen

Identifiers

PMID41102557

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.