Evidence map›Paper›PMID 41102550›Full record

ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Italian intersocietal recommendations for restructuring the diagnostic-therapeutic pathway for the implementation and appropriate use of anti-amyloid monoclonal antibodies in Alzheimer's disease.

Alberto Benussi, Federica Agosta, Alba Rosa Alfano, Antonio Antico, Giuseppe Bellelli, Laura Bonanni, Gabriella Bottini, Marco Bozzali, Ovidio Brignoli, Giuseppe Bruno and 25 more

Abstract readReview
In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Amyloid-beta-targeting monoclonal antibodies in early Alzheimer's disease: a cochrane review summary and appraisal for the neurological community.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  2. Article
  3. Mixing apples and antibodies: when the Cochrane average obscures the evidence in Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  4. Review
  5. Observational
  6. Article
  7. Observational
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Alberto BenussiNeurology Unit, Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume, 447, 34149, Trieste, Italy. benussialberto@gmail.com.ORCID http://orcid.org/0000-0002-8703-6940
Federica AgostaNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Alba Rosa AlfanoDepartment of Internal Medicine and Medical Specialties, UOC Geriatrics, Sapienza University of Rome, Rome, Italy.
Antonio AnticoDepartment of Laboratory Medicine, Hospital "Ca' Foncello", Treviso, Italy.
Giuseppe BellelliSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Laura BonanniDepartment of Medicine and Aging Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Gabriella BottiniDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Marco Bozzali"Rita Levi-Montalcini" Department of Neuroscience, University of Torino, Turin, Italy.
Ovidio BrignoliItalian College of General Practitioners and Primary Care Professionals (SIMG), Florence, Italy.
Giuseppe BrunoDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Annachiara CagninDepartment of Neuroscience, University of Padova, Padova, Italy.
Sonia Francesca CalloniNeuroradiology Unit & CERMAC, IRCCS Ospedale San Raffaele, Milan, Italy.
Diego CecchinPadua Neuroscience Center, University of Padova, Padova, Italy.
Marcello CiaccioDepartment of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy.
Sirio CocozzaDepartment of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
Mirco CosottiniNeuroradiology Unit, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Diego De LeoAustralian Institute for Suicide Research and Prevention, Griffith University, Nathan, QLD, Australia.
Andrea FaliniVita-Salute San Raffaele University, Milan, Italy.
Lorenzo GaetaniSection of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Fabio GottaUnit of Medical Genetics, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Maria InfantinoImmunology and Allergology Laboratory Unit, Ospedale San Giovanni di Dio, Azienda USL Toscana Centro, Florence, Italy.
Raffaele LodiFunctional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Giancarlo LogroscinoCenter for Neurodegenerative Diseases and the Aging Brain, University of Bari "Aldo Moro", Tricase, Lecce, Italy.
Elena MarcelloDepartment of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", University of Milan, Milan, Italy.
Camillo MarraMemory Clinic, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Walter MarroccoFederazione Italiana Medici di Medicina Generale (FIMMG), Rome, Italy.
Patrizia MecocciDivision of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Enrico MosselloDivision of Geriatric and Intensive Care Medicine, University of Florence & Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Lorenzo PalleschiUnit of Geriatrics, Medical Department, San Giovanni-Addolorata Hospital, Rome, Italy.
Leonardo PantoniNeurology and Stroke Unit, Luigi Sacco University Hospital, Milan, Italy.
Lucilla ParnettiSection of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Sandro SorbiDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
Alessandro TessitoreDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Andrea UngarDivision of Geriatric and Intensive Care Medicine, University of Florence & Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This joint Position Paper, developed by the Italian Expert Panel on Alzheimer convened by the Italian Society of Neurology with participation from multiple scientific societies, outlines strategic guidelines for reorganizing the patient journey in the era of anti-amyloid monoclonal antibodies for Alzheimer's disease. Emphasizing a multidisciplinary and integrated approach, the document recommends a patient journey that begins with early identification of cognitive impairment by General Practitioners, continues with specialized assessments at Memory and Dementia Centres, and leads, in carefully selected cases, to initiation of anti-amyloid monoclonal antibody therapy. It advocates the rational use of diagnostic tools, including plasma and cerebrospinal fluid biomarkers, advanced neuroimaging (MRI and PET), and genetic profiling (ApoE genotyping), not only to identify eligible patients but also to stratify those requiring alternative care strategies. The paper further defines minimum requirements for the accreditation of prescribing and infusion centres, highlighting the clinical competencies, structural resources, and inter-professional communication protocols necessary to ensure safety and appropriateness. Recognizing both the therapeutic potential and the organizational challenges associated with anti-amyloid monoclonal antibodies, the document aims to guide healthcare policymakers, institutions, and practitioners toward a coordinated reorganization of the diagnostic-therapeutic pathway, ensuring the safe and effective use of these treatments and ultimately improving outcomes and quality of care for individuals with Alzheimer's disease.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAntibodies, MonoclonalPractice Guidelines as TopicHumansItalyAmyloid beta-PeptidesAntibodies, MonoclonalAlzheimer’s diseaseAnti-amyloid monoclonal antibodiesBiomarkersClinical implementationDisease-modifying therapies

Identifiers

PMID41102550
PMCPMC12678623

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.