ArticleInsights into imaging2025
Can ADC changes help mRECIST or LI-RADS treatment response algorithm better diagnose pathological response of HCC after preoperative radiotherapy? Secondary analysis of a prospective phase 2 trial.
Article in Insights into imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A nomogram combining clinical variables and MR imaging features for predicting response in head-neck cancer.Insights into imaging · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
objectivesTo explore the role of apparent diffusion coefficient (ADC) changes in predicting pathological response to preoperative radiotherapy (RT) in hepatocellular carcinoma (HCC) compared to existing evaluation criteria, using histopathology as the reference standard. MATERIALS AND
methodsBuilding on the prospective clinical trial, we included 35 patients with 38 HCCs who underwent preoperative RT followed by hepatectomy between December 2014 and January 2019. Pre- and post-RT ADC parameters (ADC
resultsADC values, interquartile range, range, variance, mean absolute deviation, robust mean absolute deviation, and root mean squared increased; energy and total energy decreased; and skewness developed into negative skewness after RT. Higher Δ-ADC
conclusionsADC changes have the potential to predict the pathological response of HCC to preoperative RT, thereby enhancing current evaluation criteria. Integration of Δ-ADC CRITICAL RELEVANCE STATEMENT: Δ-ADC KEY POINTS: Precise assessment of hepatocellular carcinoma response is required for patients undergoing preoperative radiotherapy. Radiotherapy induced an increase in ADC values and heightened intratumoral heterogeneity. As the delineated region of interest expanded, AUC decreased and inter-observer agreement increased. Δ-ADC
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