Evidence map›Paper›PMID 41102531›Full record

Trial reportPediatric nephrology (Berlin, Germany)2026

Randomized cross-over comparison of double mini-PET with standard versus adapted dwell volumes and dwell times in children on chronic peritoneal dialysis.

Ariane Zaloszyc, Betti Schaefer, Maria Bartosova Medvid, Alberto Edefonti, Sara Testa, Fabio Paglialonga, Rukshana Shroff, Armelle Doutey, Johan Vande Walle, Thomas Lavaux and 7 more

Abstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ariane ZaloszycService de Pédiatrie 1, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. ariane.zaloszyc@chru-strasbourg.fr.ORCID http://orcid.org/0000-0002-2771-0999
Betti SchaeferMedical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, Clinic 1, Heidelberg, Germany.
Maria Bartosova MedvidMedical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, Clinic 1, Heidelberg, Germany.
Alberto EdefontiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Sara TestaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Fabio PaglialongaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Rukshana ShroffRenal Unit, UCL Great Ormond Street Hospital for Children, London, UK.
Armelle DouteyService de Pédiatrie 1, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Johan Vande WalleDepartment of Pediatric Nephrology, University Hospital Ghent, Ghent, Belgium.
Thomas LavauxLaboratoire de Biochimie Et Biologie Moléculaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Ludovic GladyLaboratoire de Biochimie Et Biologie Moléculaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Joris DelangheDepartment of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.
Matthijs OyaertDepartment of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.
Laura FriebusMedical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, Clinic 1, Heidelberg, Germany.
Ivan DamgovMedical Faculty Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Germany.
Michel FischbachService de Pédiatrie 1, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Claus Peter SchmittMedical Faculty Heidelberg, Center for Pediatric and Adolescent Medicine, Heidelberg University, Clinic 1, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutomated peritoneal dialysis (APD) consists of dwells with the same dwell volume and time. New cyclers allow modification of time and volume to prescribe adapted APD (AAPD), i.e., a series of short, small dwells followed by long, large dwells. Safety, efficacy, and underlying mechanisms of AAPD in children are uncertain.

methodsTwo double mini-PET were performed in randomized sequence. The standard test consisted of two identical cycles (fill volume 1000 ml/m

resultsResidual dialysate volume was 422 ± 190 ml/m

conclusionWithin the limitation of small patient numbers, this proof-of-concept study suggests similar ultrafiltration and clearance rates with a single adapted versus standard double mini-PET. High residual dialysate volumes and high IPPs highlight the challenges of AAPD prescription in children.

Indexed as

Kidney Failure, ChronicPeritoneal DialysisAdolescentChildChild, PreschoolCross-Over StudiesDialysis SolutionsFemaleHumansMaleProof of Concept StudyTime FactorsTreatment OutcomeUltrafiltrationYoung AdultDialysis SolutionsAdapted automated peritoneal dialysisChildrenIntraperitoneal pressureIntraperitoneal volumePeritoneal dialysis

Identifiers

PMID41102531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.