Evidence map›Paper›PMID 41102530›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Performance of creatinine and cystatin C-based equations to estimate glomerular filtration rate in African children with sickle cell anemia.

Agathe Bikupe Nkoy, Floreen Maluwenze Mumaka, Therance Tobo Matoka, Ange Ngonde, Ernest Kiswaya Sumaili, Justine Busanga Bukabau, Veerle Labarque, Lambertus P van den Heuvel, Arend Bökenkamp, Etienne Cavalier and 4 more

Erratum issuedAbstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Agathe Bikupe NkoyDivision of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. agath.nkoy@gmail.com.ORCID http://orcid.org/0000-0002-1563-380X
Floreen Maluwenze MumakaDivision of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Therance Tobo MatokaDivision of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Ange NgondeREZODREPANO SS, Kinshasa, Democratic Republic of Congo.
Ernest Kiswaya SumailiDivision of Nephrology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo.ORCID http://orcid.org/0000-0003-1555-7197
Justine Busanga BukabauDivision of Nephrology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo.ORCID http://orcid.org/0000-0003-3567-6927
Veerle LabarqueDepartment of Pediatric Hematology, University Hospital Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-5052-9274
Lambertus P van den HeuvelLaboratory of Pediatric Nephrology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-3917-6727
Arend BökenkampDepartment of Pediatric Nephrology, Amsterdam University Medical Center, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3492-2252
Etienne CavalierDivision of Clinical Chemistry, CHU Sart Tilman, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0003-0947-2226
Elena LevtchenkoDepartment of Pediatric Nephrology, Amsterdam University Medical Center, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-8352-7312
Pierre DelanayeDepartment of Nephrology, Dialysis, Hypertension and Transplantation, CHU Sart Tilman, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0002-1480-5761
Hans PottelDepartment of Public Health and Primary Care, KU Leuven Campus Kulak, Kortrijk, Belgium.ORCID http://orcid.org/0000-0003-0074-8919
Pépé Mfutu EkuluDivision of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo.ORCID http://orcid.org/0000-0003-0107-483X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum creatinine (SCr), the most used biomarker to evaluate glomerular filtration rate (GFR), might be inaccurate in children with sickle cell anemia (SCA). In this context, cystatin C (SCys) could be of interest. This study evaluated the performance of commonly used SCr- and SCys-based estimated GFR (eGFR) equations in African children with SCA.

methodsThis cross-sectional study included 109 steady-state children with SCA aged 3-18 years, from the Democratic Republic of Congo. Measured GFR (mGFR) was obtained using iohexol plasma clearance. eGFR was calculated using commonly used SCr- and SCys-based equations in children. The performance of these equations was evaluated by calculating the bias, precision, and accuracy within 30% (P30) of mGFR.

resultsThe mean age of participants was 9.9 ± 4.2 years, and 48.6% were female. The median mGFR was 142 (IQR 119-169) mL/min/1.73 m

conclusionThese data show that all common eGFR equations using SCr or SCys poorly predict mGFR in African children with SCA. SCr-based equations potentially miss a decline in kidney function, which suggests that SCys could be the preferred marker in this population.

Indexed as

Anemia, Sickle CellCreatinineCystatin CGlomerular Filtration RateAdolescentBiomarkersChildChild, PreschoolCross-Sectional StudiesDemocratic Republic of the CongoFemaleHumansMaleBiomarkersCreatinineCST3 protein, humanCystatin CCreatinineCystatin CEquationsGlomerular filtration rateSickle cell anemia

Identifiers

PMID41102530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.