ArticlePediatric research2025
Low platelet count, immunoglobulin resistance, and coronary artery involvement in Kawasaki disease.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Machine learning model for intravenous immunoglobulin resistance in Kawasaki disease: model development and validation study.World journal of pediatrics : WJP · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLower platelet count is associated with intravenous immunoglobulin (IVIG) resistance in Kawasaki disease (KD); paradoxically, higher count is associated with coronary artery (CA) sequelae. We addressed this inconsistency.
methodsUsing a large-scale nationwide KD database in Japan, we standardized platelet counts by age and hospital visit day. We evaluated associations between standardized platelet count and IVIG resistance using multivariable modified Poisson regression models. Associations between platelet count and CA sequelae were assessed separately among IVIG-resistant and IVIG-responsive patients.
resultsIn 41,540 patients, lower standardized platelet counts were associated with IVIG resistance in all age groups and the association increased with age: adjusted risk ratios with 95% confidence intervals per standardized platelet count decrease of 1 were 1.15 [1.06-1.25] at 0-5 months, 1.08 [1.02-1.15] at 6-11 months, 1.18 [1.14-1.22] at 1-2 years, 1.22 [1.17-1.27] at 3-4 years, and 1.26 [1.19-1.33] at ≥5 years. Lower standardized platelet count was also associated with CA sequelae in IVIG-resistant patients (1.12 [1.02-1.23]), but not in IVIG-responsive patients (0.95 [0.86-1.04]).
conclusionLower platelet counts were associated with IVIG resistance and CA sequelae in IVIG-resistant patients. Early platelet evaluation may identify high-risk patients with KD. IMPACT: Previous studies of platelet counts have shown conflicting results: lower platelet counts were associated with immunoglobulin resistance, but higher platelet counts were associated with coronary artery complications. Lower platelet counts were associated with immunoglobulin resistance across all age groups. Moreover, lower platelet counts were associated with coronary artery complications, but this association was found only in immunoglobulin-resistant patients. Our study resolves previous conflicting results by properly adjusting for age, immunoglobulin responsiveness, and platelet examination timing. Early platelet count evaluation may aid in identifying patients at high risk of immunoglobulin treatment failure and subsequent coronary involvement.
Identifiers
41102474What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.