Evidence map›Paper›PMID 41102468›Full record

Observational studyNature medicine2025

Characterizing the physiology of circulatory arrest in humans.

Jordan D Bird, Laura Hornby, Veronica Hirsch-Reinshagen, Chloe P Allen, George Isac, Peter A Gooderham, Sam D Shemie, Sonny Dhanani, Sonny Thiara, Sophie Stukas and 33 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06130033 (Characterizing the Cerebrovascular Physiology of Circulatory Death During Withdrawal of Life Sustaining Therapies in Humans), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06130033 recruitingnot on this map

Characterizing the Cerebrovascular Physiology of Circulatory Death During Withdrawal of Life Sustaining Therapies in Humans

TypeobservationalSponsorUniversity of British ColumbiaRan2023 to 2026Enrolled50ConditionsCirculatory ArrestArmsNeuromonitoring
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Jordan D BirdDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada. jordan.bird@alumni.ubc.ca.ORCID http://orcid.org/0000-0003-2548-6468
Laura HornbyDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0003-4079-8080
Veronica Hirsch-ReinshagenDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Chloe P AllenDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0009-0007-9249-232X
George IsacDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Peter A GooderhamDivision of Neurosurgery, Department of Surgery, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Sam D ShemieDivision of Pediatric Critical Care, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
Sonny DhananiDivison of Critical Care, Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.
Sonny ThiaraDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Sophie StukasDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Rebecca GreyDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0003-1731-7701
Denise A FosterDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Lauren E MaierDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0009-0009-9416-966X
Allana E LeBlancVancouver Coastal Health, Vancouver, British Columbia, Canada.
Hussein D KanjiDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Tessa F MorelliDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Andrew M AgbayDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Cheryl L WellingtonDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-7014-039X
Daljeet ChahalDivision of Gastroenterology, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Eric C BelangerDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Hezhen RenDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Pushwant S MattuDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Susan SuVancouver Coastal Health, Vancouver, British Columbia, Canada.
Chantelle T HrazdilDivision of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Jennifer PercyDivision of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Parveen SanghaVancouver Coastal Health, Vancouver, British Columbia, Canada.
Laurel V PlewesVancouver Coastal Health, Vancouver, British Columbia, Canada.
David D SweetDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Kali R RomanoDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Erik N VuDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Dean R ChittockDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Vinay K DhingraDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
William R HendersonDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Naisan R GarrawayDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
S Morad HameedDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Gordon N FinlaysonDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
David B MacLeodDepartment of Anaesthesiology, Duke University Medical Center, Durham, NC, USA.
Travis D GibbonsDepartment of Biological Sciences, Northern Arizona University, Flagstaff, AZ, USA.
Philip N AinslieCentre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia-Okanagan, Kelowna, British Columbia, Canada.
Ryan L HoilandDjavad Mowafaghian Centre for Brain Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Donald E GriesdaleDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Juan J RoncoDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Mypinder S SekhonDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Mypinder.Sekhon2@vch.ca.ORCID http://orcid.org/0000-0002-4487-301X

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) 187576Michael Smith Foundation for Health Research (MSFHR) HPI-2020-0740
6 · The paper itself

Abstract

The dying process from circulatory arrest is an underexplored domain in humans and has transdisciplinary pertinence. Here we conducted a prospective, observational cohort study of the dying process in 39 adults, with a multimodal assessment of cerebrovascular and cardiovascular physiology. We found that cerebral blood velocities and brain tissue oxygen tensions ceased before systemic hemodynamics. The brain exhibited diffusion limitation of oxygen extraction during the dying process compared with extracranial tissues. Anterior and posterior brain circulations had differences in timing of cessation of circulation and physiologic responses during the dying process. Blood-based neurologic biomarkers from the brain did not change during the associated ischemia related to the dying process. Heart pathology was associated with the length of the dying process. This study provides proof-of-concept of an in vivo human model to comprehensively investigate severe cerebral ischemia and the human dying process. ClinicalTrials.gov registration: NCT06130033 .

Indexed as

Heart ArrestAdultAgedBrainBrain IschemiaCerebrovascular CirculationFemaleHemodynamicsHumansMaleMiddle AgedOxygenProspective StudiesOxygen

Identifiers

PMID41102468
PMCPMC12532612

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.