Evidence map›Paper›PMID 41102440›Full record

ReviewInfectious diseases and therapy2025

Metabolomics of Sepsis and Acute Kidney Injury in Infants and Children: Current Challenges in Prevention, Diagnosis, and Management.

Vanda Koko, Vy Nguyen, Sean N Avedissian, Daniel Son, Victor Trinh, Kevin Tran, Dylan H Do, Tri M Tran, Lana Hoang, Zhixiong Wang and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Infectious diseases and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Vanda Koko *Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA.
Vy Nguyen *Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA.
Sean N AvedissianCollege of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Daniel SonSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA.
Victor TrinhSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA.
Kevin TranSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA.
Dylan H DoDartmouth College, Hanover, NH, USA.
Tri M TranKaiser Permanente, Los Angeles, CA, USA.
Lana HoangSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA.
Zhixiong WangSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA.
Jacinda Abdul-MutakabbirSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA.
Jennifer LeSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA. jenle@health.ucsd.edu.ORCID http://orcid.org/0000-0002-6692-0884

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis and acute kidney injury (AKI) are significant contributors to morbidity and mortality in neonates, infants, and children. This comprehensive review aimed to evaluate the application of metabolomics in the challenging diagnostic process of sepsis and AKI in neonatal and pediatric populations. We highlighted the role of metabolomic profiling in enabling the accurate identification of biomarkers associated with sepsis and AKI, allowing for the timely prevention or detection of the disease. Additionally, pharmacometabolomics was presented to ascertain the contribution of metabolomics towards optimizing an individual's drug therapy via direct measurement and monitoring of drug metabolites to predict the pharmacokinetic profiles of drug compounds. This review also addressed the obstacles in translating metabolomic research into clinical practice, including the need for standardized methodologies, age-specific reference data, and large-scale validation studies as a result of the current limited literature in this area. Ultimately, the review showcased how utilizing metabolomics-driven diagnostic and treatment guidelines can promote positive clinical outcomes in infants and children affected by sepsis-associated AKI.

Indexed as

Acute kidney injuryMetabolomicsNeonatesPediatricsPharmacometabolomicsSepsis

Identifiers

PMID41102440
PMCPMC12602828

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.