Evidence map›Paper›PMID 41102390›Full record

ArticleNPJ digital medicine2025

A multimodal uncertainty-aware AI system optimizes ovarian cancer risk assessment workflow.

Xiaodong Wang, Xiaohui Lv, Jingwen Wang, Lulu Zou, Zijun Chen, Ruiyu Zhao, Lisha Zhao, Min Zhao, Xinlei Zhang, Boan Zhang and 9 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xiaodong Wang *School of Computer Science and Technology, Xidian University, Xi'an, China.
Xiaohui Lv *Department of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Jingwen Wang *School of Computer Science and Technology, Xidian University, Xi'an, China.
Lulu ZouDepartment of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Zijun ChenDepartment of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Ruiyu ZhaoSchool of Computer Science and Technology, Xidian University, Xi'an, China.
Lisha ZhaoDepartment of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Min ZhaoDepartment of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Xinlei ZhangSchool of Computer Science, Northwestern Polytechnical University, Xi'an, China.
Boan ZhangSchool of Computer Science and Technology, Xidian University, Xi'an, China.
Jiahao ZhangSchool of Computer Science and Technology, Xidian University, Xi'an, China.
Yiteng ZhuSchool of Computer Science and Technology, Xidian University, Xi'an, China.
Xin ShiDepartment of Gynecology and Obstetrics, Xi'an People's Hospital, Xi'an Fourth Hospital, Xi'an, China.
Yan'e GaoDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Minghui LiuDepartment of Gynecology and Obstetrics, Xi'an Aerospace Hospital, Xi'an, China.
Lirong AiSchool of Computer Science, Northwestern Polytechnical University, Xi'an, China.
Liming WangSchool of Computer Science and Technology, Xidian University, Xi'an, China. wanglm@mail.xidian.edu.cn.
Xiyang LiuSchool of Computer Science and Technology, Xidian University, Xi'an, China. xyliu@xidian.edu.cn.
Hong YangDepartment of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University, Xi'an, China. yanghong@fmmu.edu.cn.

Funding

Key Research and Development Projects of Shaanxi Province 2022ZDLSF04-04National Natural Science Foundation of China 82172860Natural Science Foundation of China 82103037Natural Science Foundation of China 82172993Natural Science Foundation of Shaanxi Province, China 2024JC-ZDXM-52Shaanxi Provincial Innovation 2023PT-07Shaanxi Provincial Key Industry Innovation Chain 2024SF-ZDCYL-01-17
6 · The paper itself

Abstract

Accurate ovarian cancer screening and diagnosis are critical for patient survival. We present UMORSS, an AI-assisted diagnostic system integrating ultrasound (US) imaging and clinical data with uncertainty quantification for precise ovarian cancer risk assessment. Developed and evaluated using a multicentre dataset (7352 patients, 7594 lesions, 9281 US images), UMORSS employs a two-phase approach: Phase I rapidly triages low-risk lesions via initial US analysis, and Phase II provides uncertainty-aware multimodal analysis for complex cases. Phase I accurately identified 68.7% of physiological cysts and 13.8% of benign tumours as low-risk, with zero false negatives, and Phase II achieved an AUC of 0.955 (internal testing) and 0.926 (external validation). Furthermore, a prospective reader study (n = 284 cases, six radiologists) demonstrated that UMORSS as a human-AI collaborative tool increased radiologists' average AUC by 10.58% and sensitivity by 22.48%. UMORSS shows strong potential to streamline clinical workflow, optimize resource allocation, and standardize ovarian cancer diagnosis.

Identifiers

PMID41102390
PMCPMC12533055

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.