ArticleScientific reports2025
Selective laser etching fabrication of stacked microporous membranes for multisize particle separation in 3D microfluidics.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Engineering human multi-organ tissue chip niches for drug absorption, distribution, metabolism, excretion and toxicity prediction.Nature biomedical engineering · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Glass substrates are widely utilized in microfluidic applications due to their exceptional properties, including optical transparency, biocompatibility, chemical and thermal stability, and compatibility with standard microfabrication techniques. These characteristics enable high-resolution micro- and nanopatterning through methods such as wet and dry etching, laser ablation, and photolithography, facilitating the fabrication of complex and reproducible microfluidic components-such as microchannels, microchambers, micropumps, mixers, sensors, and membranes. In this study we leverage femtosecond technology to fabricate a novel multilayer microfluidic system that integrates two porous membranes, with precisely engineered pore geometries. Fabrication of the multilayer device was based on a selective laser etching process (SLE) using a glass 3D printer (LightFab GmbH, Germany), to obtain microchannels and membranes with pore sizes of 5 [Formula: see text]m and 25 [Formula: see text]m. The SLE sequence was optimized to minimize thermal ablation, preserving pore integrity and achieving high fidelity in pore size and distribution. Potassium hydroxide (KOH) was used for wet etching, leveraging the selectivity of fused silica to further refine pore geometry. A microwelding technique was optimized to achieve a consistent interlayer gap, essential for structural integrity and effective filtration. Results of filtration tests demonstrated that 30 [Formula: see text]m particles were selectively trapped in 25 [Formula: see text]m-pore membranes and 8 [Formula: see text]m particles were selectively trapped in 5 [Formula: see text]m filters, while both membranes allow the passage of 2 [Formula: see text]m particles. These results validate the ability of the system to perform size-based separation in microfluidic environments, highlighting the potential of femtosecond laser-based fabrication to produce robust, scalable, multilayer filtration devices for high throughput applications. This approach opens new avenues for developing integrated microfluidic systems capable of simultaneous filtration, separation, and analysis, paving the way for automated lab-on-a-chip applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.