Evidence map›Paper›PMID 41102297›Full record

ArticleScientific reports2025

Multimodal predictors of disability progression and processing speed decline in relapsing-remitting multiple sclerosis.

Max Korbmacher, Ingrid Anne Lie, Kristin Wesnes, Eric Westman, Thomas Espeseth, Karsten Specht, Ole Andreas Andreassen, Lars Tjelta Westlye, Stig Wergeland, Kjell-Morten Myhr and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Max KorbmacherDepartment for Radiography, Western Norway University of Applied Sciences, Bergen, Norway. max.korbmacher@hvl.no.
Ingrid Anne LieDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Kristin WesnesDepartment of Neurology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
Eric WestmanDepartment of Neurobiology, Karolinska Instituttet, Stockholm, Sweden.
Thomas EspesethDepartment of Psychology, University of Oslo, Oslo, Norway.
Karsten SpechtDepartment of Radiology, Mohn Medical Imaging and Visualisation Center, Haukeland University Hospital, Bergen, Norway.
Ole Andreas AndreassenCenter for Precision Psychiatry, University of Oslo and Oslo University Hospital, Oslo, Norway.
Lars Tjelta WestlyeDepartment of Psychology, University of Oslo, Oslo, Norway.
Stig WergelandDepartment for Radiography, Western Norway University of Applied Sciences, Bergen, Norway.
Kjell-Morten MyhrDepartment for Radiography, Western Norway University of Applied Sciences, Bergen, Norway.
Øivind Torkildsen *Department for Radiography, Western Norway University of Applied Sciences, Bergen, Norway.
Einar August Høgestøl *Department of Neurology, Oslo University Hospital, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The underlying mechanisms for neurodegeneration in multiple sclerosis are complex and incompletely understood. Multivariate and multimodal investigations integrating demographic, clinical, multi-omics, and neuroimaging data provide opportunities for nuanced analyses, aimed to define disease progression markers. We used data from a 12-year longitudinal multicenter cohort of 88 people with multiple sclerosis, to test the predictive value of multi-omics, T

Indexed as

Multiple Sclerosis, Relapsing-RemittingProcessing SpeedAdultDisability EvaluationDisease ProgressionFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedQuality of LifeDisease course predictionMultiversePatient-reported outcome measuresSpecification curve

Identifiers

PMID41102297
PMCPMC12533244

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.