ArticleNature communications2025
DNA StairLoop: enabling high-fidelity data recovery and robust error correction in DNA-based data storage.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Quantitative Assessment of Randomized DNA Base Sequences Using Multi-Model Physical Analysis for High-Fidelity Data Storage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- DNA StairLoop: enabling high-fidelity data recovery and robust error correction in DNA-based data storage.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
High-throughput electrochemical synthesis is an emerging DNA synthesis technology that has attracted considerable attention due to its scalability and cost-effectiveness. However, its high error rates and poor synthesis uniformity pose significant challenges for applications in DNA data storage, where high fidelity is essential. In this study, we present StairLoop, a coding scheme designed to address these error characteristics, providing robust error-correcting capabilities. Validated through in-vitro experiments, StairLoop successfully recovers original data under harsh conditions, including nucleotide error rates exceeding 6% or dropout rates over 30% within a block, with sequencing depths of less than 3x . Moreover, the simulation results show that StairLoop can achieve an error correction capability of 10% at the mean coverage rate of 15x. These results highlight StairLoop's potential to enhance the reliability and practicality of electrochemical DNA synthesis for data storage applications.
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Registered trials
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