Evidence map›Paper›PMID 41102184›Full record

ArticleNature communications2025

Zinc finger domains bind low-complexity domain polymers.

Naohiko Iguchi, Noriyoshi Isozumi, Yoshikazu Hattori, Tomohiro Imamura, Takeshi Yokoyama, Masatomo So, Hitoki Nanaura, Takao Kiriyama, Nobuyuki Eura, Minako Yamaoka and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Naohiko Iguchi *Department of Neurology, Nara Medical University, Kashihara, Nara, Japan.ORCID http://orcid.org/0000-0003-4382-5902
Noriyoshi Isozumi *Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan.
Yoshikazu HattoriDivision of Molecular Life Science, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
Tomohiro ImamuraDepartment of Bioproduction Science, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.ORCID http://orcid.org/0000-0003-2277-9134
Takeshi YokoyamaGraduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0002-0299-9140
Masatomo SoDepartment of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan.ORCID http://orcid.org/0000-0002-4815-4995
Hitoki NanauraDepartment of Neurology, Nara Medical University, Kashihara, Nara, Japan.ORCID http://orcid.org/0000-0002-0934-7065
Takao KiriyamaDepartment of Neurology, Nara Medical University, Kashihara, Nara, Japan.ORCID http://orcid.org/0000-0002-2282-0849
Nobuyuki EuraDepartment of Neurology, Nara Medical University, Kashihara, Nara, Japan.ORCID http://orcid.org/0000-0002-4943-3152
Minako YamaokaDepartment of Neurology, Nara Medical University, Kashihara, Nara, Japan.
Naoki IwasaDepartment of Neurology, Nara Medical University, Kashihara, Nara, Japan.
Tomo ShiotaDepartment of Neurology, Nara Medical University, Kashihara, Nara, Japan.
Mari NakanishiV-iCliniX Laboratory, Nara Medical University, Kashihara, Nara, Japan.
Nanako KonishiDepartment of Neurology, Nara Medical University, Kashihara, Nara, Japan.
Haruka ItoDepartment of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan.
Akihito TakeuchiDepartment of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan.
Masashi MoriResearch Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.
Shinya OhkiCenter for Nano Materials and Technology (CNMT), Japan Advanced Institute of Science and Technology (JAIST), Nomi, Ishikawa, Japan.
Hiroyuki KumetaFaculty of Advanced Life Science, Hokkaido University, Sapporo, Hokkaido, Japan.ORCID http://orcid.org/0000-0003-3713-2122
Hironori KogaDepartment of Bioproduction Science, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.
Mai WatabeFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Miyagi, Japan.
Takuya MabuchiFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0001-8253-4273
Shingo KanemuraFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0002-7012-8179
Masaki OkumuraFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0001-8130-2470
Yoshikazu TanakaGraduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0002-7893-3236
Ken MorishimaInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Sennan-gun, Osaka, Japan.
Masaaki SugiyamaInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Sennan-gun, Osaka, Japan.
Fumika IdeCollege of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.
Hiroyoshi MatsumuraCollege of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.ORCID http://orcid.org/0000-0003-0361-3796
Takuya YoshizawaCollege of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.
Ichiro OtaDepartment of Otolaryngology‑Head and Neck Surgery, Kindai University Nara Hospital, Ikoma, Nara, Japan.
Naoki SuzukiDepartment of Neurology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.ORCID http://orcid.org/0000-0001-8880-8554
Masashi AokiDepartment of Neurology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.
Yoshito YamashiroDepartment of Advanced Medical Technologies, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
Tomohide SaioDivision of Molecular Life Science, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.ORCID http://orcid.org/0000-0003-3639-7399
Kazuma SugieDepartment of Neurology, Nara Medical University, Kashihara, Nara, Japan. ksugie@naramed-u.ac.jp.ORCID http://orcid.org/0000-0003-0148-4687
Eiichiro MoriDepartment of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan. emori@naramed-u.ac.jp.ORCID http://orcid.org/0000-0003-0945-196X

Funding

Japan Agency for Medical Research and Development (AMED) JP24wm0425004MEXT | Japan Society for the Promotion of Science (JSPS) JP20H03199
6 · The paper itself

Abstract

Self-association of low-complexity protein sequences (LC domains) is important for polymer formation. Several molecular chaperones are involved in the regulation of LC domain polymer formation. However, the mechanisms underlying cell recognition of LC domain polymers remain unclear. Here we show that zinc finger domains (ZnFs) bind LC domains of RNA-binding proteins in a cross-β polymer-dependent manner. ZnFs bound to LC domain hydrogels and suppressed LC domain polymer formation. Moreover, ZnFs preferentially recognize LC domains in the polymeric state. These findings suggest that ZnFs act as physiological regulators of LC domain polymer formation.

Indexed as

PolymersRNA-Binding ProteinsZinc FingersHumansHydrogelsProtein BindingProtein DomainsHydrogelsPolymersRNA-Binding Proteins

Identifiers

PMID41102184
PMCPMC12531337

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.