ArticleNPJ science of food2025
Functional gut variability drives metabolic and transcriptional features in neonatal piglets.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.Food chemistry. Molecular sciences · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
The inherent inter-individual variability and associated complexity of dietary response constitute a major research challenge, but also present an opportunity to trace personalized patterns that may serve as targets for improving health. Here, we investigated the function of α-lactalbumin, a rich source of tryptophan, in a formula feeding study. We leveraged neonatal piglets as a preclinical model for human infants and took a systems-level approach that integrates evidence from serum, urine, liver, brain, and the gastrointestinal tract. Transcriptional and metabolomics analysis revealed an individualized, divergent response to α-lactalbumin linked to either efficient utilization of tryptophan by the host or production of indole-3-lactate by intestinal microbiota. This variability was further highlighted by differences in metabolic and immunological effects in a tissue-specific manner. Our work highlights the importance of considering the nutrition-microbiota-host metabolism axis to optimize the phenotypic response of a diet.
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Registered trials
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