Evidence map›Paper›PMID 41102159›Full record

ArticleNature communications2025

Pushing the boundary of quantum advantage in hard combinatorial optimization with probabilistic computers.

Shuvro Chowdhury, Navid Anjum Aadit, Andrea Grimaldi, Eleonora Raimondo, Atharva Raut, P Aaron Lott, Johan H Mentink, Marek M Rams, Federico Ricci-Tersenghi, Massimo Chiappini and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shuvro ChowdhuryDepartment of Electrical and Computer Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. schowdhury@ucsb.edu.ORCID http://orcid.org/0000-0002-6325-0790
Navid Anjum AaditDepartment of Electrical and Computer Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID http://orcid.org/0000-0001-9933-0728
Andrea GrimaldiDepartment of Mathematical and Computer Sciences, Physical Sciences and Earth Sciences, University of Messina, 98166, Messina, Italy.ORCID http://orcid.org/0000-0002-8052-0764
Eleonora RaimondoDepartment of Mathematical and Computer Sciences, Physical Sciences and Earth Sciences, University of Messina, 98166, Messina, Italy.ORCID http://orcid.org/0000-0002-6512-988X
Atharva RautDepartment of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID http://orcid.org/0009-0006-0047-1090
P Aaron LottUSRA Research Institute for Advanced Computer Science (RIACS), Mountain View, CA, USA.
Johan H MentinkRadboud University, Institute for Molecules and Materials, Heyendaalseweg 135, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-4082-1984
Marek M RamsInstitute of Theoretical Physics, Jagiellonian University, Lojasiewicza 11, PL-30348, Kraków, Poland.ORCID http://orcid.org/0000-0002-1235-7758
Federico Ricci-TersenghiDipartimento di Fisica, Sapienza Università di Roma, and CNR-Nanotec, Rome unit and INFN, Sezione di Roma 1, 00185, Rome, Italy.ORCID http://orcid.org/0000-0003-4970-7376
Massimo ChiappiniIstituto Nazionale di Geofisica e Vulcanologia, Via di Vigna Murata 605, 00143, Roma, Italy.ORCID http://orcid.org/0000-0001-7433-9435
Luke S TheogarajanDepartment of Electrical and Computer Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.ORCID http://orcid.org/0000-0002-0320-5023
Tathagata SrimaniDepartment of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Giovanni FinocchioDepartment of Mathematical and Computer Sciences, Physical Sciences and Earth Sciences, University of Messina, 98166, Messina, Italy.ORCID http://orcid.org/0000-0002-1043-3876
Masoud MohseniEmergent Machine Intelligence, Hewlett Packard Labs, Palo Alto, CA, USA.
Kerem Y CamsariDepartment of Electrical and Computer Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. camsari@ucsb.edu.ORCID http://orcid.org/0000-0002-6876-8812

Funding

National Science Foundation (NSF) CCF 2106260United States Department of Defense | United States Army | U.S. Army Research, Development and Engineering Command | Army Research Laboratory (U.S. Army Research Laboratory) W911NF-24-1-0228
6 · The paper itself

Abstract

Recent demonstrations on specialized benchmarks have reignited excitement for quantum computers, yet their advantage for real-world problems remains an open question. Here, we show that probabilistic computers, co-designed with hardware to implement Monte Carlo algorithms, provide a scalable classical pathway for solving hard optimization problems. We focus on two algorithms applied to three-dimensional spin glasses: discrete-time simulated quantum annealing and adaptive parallel tempering. We benchmark these methods against a leading quantum annealer. For simulated quantum annealing, increasing replicas improves residual energy scaling, consistent with extreme value theory. Adaptive parallel tempering, supported by non-local isoenergetic cluster moves, scales more favorably and outperforms simulated quantum annealing. Field Programmable Gate Arrays or specialized chips can implement these algorithms in modern hardware, leveraging massive parallelism to accelerate them while improving energy efficiency. Our results establish a rigorous classical baseline for assessing practical quantum advantage and present probabilistic computers as a scalable platform for real-world optimization challenges.

Identifiers

PMID41102159
PMCPMC12533262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.