ArticleBritish journal of anaesthesia2026
Factors associated with long-term opioid therapy discontinuation for people with chronic non-cancer pain in UK primary care: a population-based retrospective cohort study.
Article in British journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A Metal-Polyphenol Complex Eliminates Chondrocytic ROS to Ameliorate Osteoarthritis.Cartilage · 2026Article
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6 authors.
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Abstract
backgroundUnderstanding the characteristics linked to long-term opioid therapy (L-TOT) discontinuation may inform safer and personalised discontinuation strategies. This study aimed to identify factors associated with L-TOT discontinuation in people with chronic non-cancer pain (CNCP) in UK primary care.
methodsA retrospective cohort study using the Clinical Practice Research Datalink Aurum data (2000-2020) was conducted. Adults with CNCP receiving L-TOT (three or more opioid prescriptions within 90 days or ≥90 days' supply within the first year, excluding the first 30 days) were included. Discontinuation was defined as opioid-free for ≥180 days after an L-TOT. Mixed-effects logistic models with a random intercept for general practice were used to identify sociodemographic, comorbidities, lifestyle, and pharmacological factors associated with L-TOT discontinuation.
resultsAmong 573 639 L-TOT users, 5.2% (n=29 589) discontinued within the first year. Discontinuation was more likely among Asians (adjusted odds ratio [aOR], 1.31; 95% confidence interval [CI], 1.23-1.39; P<0.001), Blacks (aOR, 1.21; 95% CI, 1.13-1.31; P<0.001), non-smokers (aOR, 1.09; 95% CI, 1.05-1.12; P<0.001), those living in the least deprived area (aOR, 1.09; 95% CI, 1.04-1.14; P<0.001), those using weak and short-acting opioids (aOR, 1.50; 95% CI, 1.39-1.61), those with co-existing osteoarthritis (aOR, 1.06; 95% CI, 1.02-1.11; P=0.003), those with anxiety (aOR, 1.04; 95% CI, 1.01-1.07; P=0.003), or those co-using non-steroidal anti-inflammatory drugs (aOR, 1.06; 95% CI, 1.03-1.09; P<0.001) or benzodiazepines (aOR, 1.08; 95% CI, 1.05-1.11; P<0.001).
conclusionsThis study identified key characteristics of people with chronic non-cancer pain who are more likely to discontinue long-term opioid therapy. This may help to inform the development of tailored interventions to promote safe opioid discontinuation in primary care.
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