Evidence map›Paper›PMID 41102014›Full record

ArticleBiomacromolecules2025

Engineered Sulfonated Bacterial Cellulose Hydrogel with Dual Bioactive-Drug Delivery Functions for Precision Treatment of Psoriasis.

Liangliang Zhang, Xvyue Zhou, Xinmeng Li, Kun Wang, Peng Zhou, Weixiao Ding, Jian Cui, Yalei Qiao, Shudai Huang, Chao Luan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liangliang ZhangHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China.
Xvyue ZhouHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China.
Xinmeng LiInstitute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Kun WangSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.ORCID 0000-0001-9636-9264
Peng ZhouInstitute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Weixiao DingInstitute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Jian CuiInstitute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Yalei QiaoInstitute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Shudai HuangHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China.
Chao LuanHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China.
Lei ZhangInstitute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Kun ChenHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China.
Jiaan ZhangHospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China.ORCID 0000-0002-3984-3860

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is a chronic, inflammatory skin disorder driven by dysregulated keratinocyte-immune interactions and oxidative stress. To address limitations of conventional therapies, we engineered a sulfated bacterial cellulose/chitosan hydrogel that integrates intrinsic bioactivity with controlled methotrexate delivery (MTX-SBC/CS Gel). Sulfonation introduced sulfonic groups, conferring potent ROS-scavenging activity while optimizing drug compatibility and release kinetics. Chitosan enabled self-healing and bioadhesion through hydrogen-bonding networks. Molecular simulations and experiments revealed how sulfonic groups modulate drug-polymer interactions. In imiquimod-induced psoriatic models, MTX-SBC/CS Gel exhibited therapeutic efficacy comparable to that of the clinical standard betamethasone, with SBC alone showing beneficial effects; both accelerated epidermal normalization, and cytokine suppression. Transcriptomics identified SBC's multimodal mechanism: downregulation of IL-23/Th17 axis components, inhibition of keratinocyte hyperproliferation, and restoration of redox homeostasis via HSP90α-mediated pathways. The synergistic integration of sulfonation-enabled ROS scavenging, and optimized MTX release kinetics establishes this engineered hydrogel as a promising platform for the management of dermatoses.

Indexed as

CelluloseDrug Delivery SystemsHydrogelsMethotrexatePsoriasisAnimalsChitosanHumansKeratinocytesMiceCelluloseChitosanHydrogelsMethotrexate

Identifiers

PMID41102014
PMCPMC12609078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.