Evidence map›Paper›PMID 41101967›Full record

ArticleAnnals of geriatric medicine and research2025

Sex-specific All-cause Mortality is Associated with Adiposity in the Malaysian Elders Longitudinal Research (MELoR) Study.

Nurul Nabilah Akmal Hashim, Sumaiyah Mat, Phyo Kyaw Myint, Mirela Delibegovic, Sheng Hui Kioh, Shahrul Bahyah Kamaruzzaman, Noran Naqiah Hairi, Selina Khoo, Ai-Vyrn Chin, Maw Pin Tan

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Article in Annals of geriatric medicine and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Nurul Nabilah Akmal HashimAgeing and Age-Associated Disorders Research Group, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Sumaiyah MatAgeing and Age-Associated Disorders Research Group, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Phyo Kyaw MyintAgeing Clinical & Experimental Research Team, Institute of Applied Health Sciences, University of Aberdeen, UK.
Mirela DelibegovicAberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, University of Aberdeen, UK.
Sheng Hui KiohAgeing and Age-Associated Disorders Research Group, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Shahrul Bahyah KamaruzzamanAgeing and Age-Associated Disorders Research Group, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Noran Naqiah HairiAgeing and Age-Associated Disorders Research Group, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Selina KhooFaculty of Sport and Exercise Sciences, Universiti Malaya, Kuala Lumpur, Malaysia.
Ai-Vyrn ChinAgeing and Age-Associated Disorders Research Group, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Maw Pin TanAgeing and Age-Associated Disorders Research Group, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.

Funding

Malaysian Ministry of Higher Education Long-Term Research Grant Scheme LRGS/1/2019/UM//1/1
6 · The paper itself

Abstract

backgroundWhile adiposity has been found to be protective against adverse outcomes in older adults, the role of muscle in this association remains underexplored. This study sought to evaluate sex-specific mortality associated with available adiposity indices in older adults and the potential role of muscle strength in this relationship.

methodsIndividuals aged ≥55 years were recruited from 2013 to 2015. Adiposity indices obtained were body mass index (BMI), percentage body fat (%BF), waist-to-hip ratio (WHR), and waist circumference (WC). Vital status up to June 2022 was determined through the National Registry Department.

resultsOf the 1,347 included participants, mean age of 68.45±7.21 years, 57.1% female, and 11.2% deaths were recorded. Male who were underweight had increased mortality compared to male with normal BMI (hazard ratio [HR]=3.17, 95% confidence interval [CI] 1.35-7.47). Mortality was greater in male with %BF within the highest quartile (Q4) compared to the lowest quartile (Q1) (HR=4.72, 95% CI 2.07-10.78). Increased mortality in both male and female in Q4 for WHR compared to Q1 was influenced by age, as was increased mortality in female in Q4 for %BF. WC did not predict mortality in male or female. Increased mortality risk was present in male with normal muscle strength and increased %BF, and reduced muscle strength in male with low BMI.

conclusionsAdiposity measured with BMI, WHR and WC had limited value in determining mortality risk at 9-year follow-up among individuals aged ≥55 years. Increased mortality was, however, observed in male with higher %BF but this could not be attributed to muscle strength.

Indexed as

AdiposityMortalityAgedBody Mass IndexCause of DeathFemaleHumansLongitudinal StudiesMalaysiaMaleMiddle AgedMuscle StrengthRisk FactorsSex FactorsWaist CircumferenceWaist-Hip RatioAgedBody compositionMortalityMuscle strengthObesity

Identifiers

PMID41101967
PMCPMC12766298

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