Evidence map›Paper›PMID 41101787›Full record

ArticleRMD open2025

Autoantibodies directed against the angiotensin II type 1 receptor and the endothelin-1 type A receptor in patients with systemic sclerosis.

Katherine E van der Wouden, Saad Ahmed, Wieke M van Oostveen, Eva M Hoekstra, Sophie I E Liem, Tom W J Huizinga, René E M Toes, Alexandre E Voskuyl, Gabriela Riemekasten, Cynthia M Fehres and 2 more

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Article in RMD open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Katherine E van der WoudenDepartment of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0009-0001-8238-1649
Saad AhmedDepartment of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-3098-0172
Wieke M van OostveenDepartment of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.
Eva M HoekstraDepartment of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.
Sophie I E LiemDepartment of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0003-0328-7062
Tom W J HuizingaDepartment of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-7033-7520
René E M ToesDepartment of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-9618-6414
Alexandre E VoskuylDepartment of Rheumatology and Clinical Immunology, Amsterdam University Medical Center, Amsterdam, Netherlands.
Gabriela RiemekastenDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Cynthia M FehresDepartment of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.
Madelon VonkDepartment of Rheumatic Diseases, Radboud University Medical Center, Nijmegen, Netherlands.ORCID 0000-0002-2266-9907
Jeska K de Vries-BouwstraDepartment of Rheumatology, Leiden University Medical Center, Leiden, Netherlands j.k.de_Vries-Bouwstra@lumc.nl.ORCID 0000-0002-5624-1415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the clinical applicability of autoantibodies (AAbs) measured by ELISA against the angiotensin II type 1 receptor (AT

methodsSerum samples from n=279 SSc patients from the Leiden Systemic Sclerosis cohort, n=42 patients with primary Raynaud's phenomenon, n=24 patients with rheumatoid arthritis and n=20 healthy controls were tested for anti-AT

resultsAAbs against AT

conclusionsWe confirm positive ELISAs for anti-AT

Indexed as

AutoantibodiesLung Diseases, InterstitialReceptor, Angiotensin, Type 1Receptor, Endothelin AScleroderma, SystemicAdultAgedArthritis, RheumatoidCase-Control StudiesCause of DeathEnzyme-Linked Immunosorbent AssayFemaleHealthy VolunteersHumansMaleMiddle AgedAutoantibodiesReceptor, Angiotensin, Type 1Receptor, Endothelin AAutoantibodiesAutoimmune DiseasesBiomarkersSystemic Sclerosis

Identifiers

PMID41101787
PMCPMC12530366

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.