ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025
Biomarkers of organ stress and injury following the Boston Marathon.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We examined the changes in blood and urine-based biomarkers of organ stress/injury and hydration before and after the 2024 Boston Marathon. Our primary aims were to compare responses between males and females, and euhydrated and hypohydrated runners. Seventy-two runners (34 males/38 females; 50 ± 11 yr; finish time 3:45 ± 0:32 h:min) had blood and/or urine samples taken before and after the race. Average temperature on a race day was 19 ± 3°C, and relative humidity was 47 ± 15%. Samples were assayed for markers of hydration, intestinal injury (intestinal fatty acid binding protein and soluble cluster of differentiation 14), skeletal muscle damage (creatine kinase), and acute kidney injury (tissue inhibitor of metalloproteinase 2, insulin-like growth factor binding protein 7, neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, creatinine). Markers of hydration were elevated from pre- to postrace, but only 25%-34% of runners were deemed hypohydrated postrace. All markers of organ stress/injury were increased postrace (fold change: 1.3-1455;
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