Evidence map›Paper›PMID 41101777›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Postnatal developmental dynamics of mitochondrial complex I in mouse tissues.

Max Siragusa, Belem Yoval-Sánchez, Ivan Guerrero, Alexander Galkin

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Max SiragusaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, United States.
Belem Yoval-SánchezFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, United States.ORCID 0000-0002-7276-278X
Ivan GuerreroFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, United States.
Alexander GalkinFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, United States.ORCID 0000-0001-8469-2283

Funding

The Role of FMN Loss by Mitochondrial Complex I in Neonatal Hypoxic-Ischemic Brain InjuryR01NS112381 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GALKIN, ALEXANDER · 2020 to 2024
$2.1M
Metabolic Landscape and Mitochondrial ROS Balance in Brain Ischemia/ReperfusionR01NS131322 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Alexander Galkin, Steven S Gross · 2024 to 2026
$1.6M
Ultra-sensitive multi-mode laser-scanning imaging systemS10OD030335 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI JAFFREY, SAMIE R · 2021 to 2021
$163k
HHS | National Institutes of Health (NIH) R01NS112381HHS | National Institutes of Health (NIH) S10OD030335HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS131322NIH HHS S10 OD030335NINDS NIH HHS R01 NS112381NINDS NIH HHS R01 NS131322
6 · The paper itself

Abstract

Although the content of mitochondrial enzymes in different tissues can vary greatly, understanding the regulation behind these differences has been hampered by a lack of quantitative knowledge in relation to postnatal development. Here we report a quantitative analysis of developing brain, heart, kidneys, and muscle tissue of C57BL/6J mice, focusing on the content of mitochondrial complex I, a key component of the respiratory chain. We found that in all tissues except kidneys, complex I content gradually increases after birth, reaching a plateau level at around 25 days. Complex I content in muscles does not change significantly until

Indexed as

BrainElectron Transport Complex IKidneyMitochondriaAnimalsAnimals, NewbornFemaleMaleMiceMice, Inbred C57BLMuscle, SkeletalMyocardiumOxidative PhosphorylationElectron Transport Complex Iflavoproteinsmitochondrial complex Imouse mitochondrial developmentnative protein electrophoresisrespiratory chain

Identifiers

PMID41101777
PMCPMC12700496

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.