Evidence map›Paper›PMID 41101717›Full record

ArticleGene expression patterns : GEP2025

Mapping Shroom3 expression across the adult mouse.

Jennifer L Carleton, Dewmini Dematagoda, Meg A Schuurman, Jessica A Willson, Bonnie Wu, Kyra Ball, Timothy F Plageman, Darren Bridgewater, Thomas A Drysdale

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene expression patterns : GEP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jennifer L CarletonChildren's Health Research Institute, Victoria Research Labs, 790 Commissioners Road East, London, Ontario, N6A 4L6, Canada; Department of Physiology & Pharmacology, The University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada. Electronic address: jcarlet@uwo.ca.
Dewmini DematagodaChildren's Health Research Institute, Victoria Research Labs, 790 Commissioners Road East, London, Ontario, N6A 4L6, Canada; Department of Physiology & Pharmacology, The University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada.
Meg A SchuurmanChildren's Health Research Institute, Victoria Research Labs, 790 Commissioners Road East, London, Ontario, N6A 4L6, Canada; Department of Physiology & Pharmacology, The University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada.
Jessica A WillsonChildren's Health Research Institute, Victoria Research Labs, 790 Commissioners Road East, London, Ontario, N6A 4L6, Canada; Department of Paediatrics, The University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada.
Bonnie WuCollege of Optometry, The Ohio State University, Columbus, OH, 43210, USA.
Kyra BallDepartment of Pathology & Molecular Medicine, Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, L8S 4L8, Canada.
Timothy F PlagemanCollege of Optometry, The Ohio State University, Columbus, OH, 43210, USA.
Darren BridgewaterDepartment of Pathology & Molecular Medicine, Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, L8S 4L8, Canada.
Thomas A DrysdaleChildren's Health Research Institute, Victoria Research Labs, 790 Commissioners Road East, London, Ontario, N6A 4L6, Canada; Department of Physiology & Pharmacology, The University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada; Department of Paediatrics, The University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada.

Funding

Characterizing the fundamental mechanisms of epithelial invagination during ocular morphogenesisR01EY026910 · NEI · OHIO STATE UNIVERSITY · PI PLAGEMAN, TIMOTHY F · 2016 to 2020
$1.9M
NEI NIH HHS R01 EY026910
6 · The paper itself

Abstract

Shroom3 is an actin binding protein integral to apical constriction and apical-basal elongation during mammalian morphogenesis. Shroom3 function has been demonstrated in the development of the heart, neural tube, gut tube, eye, thyroid bud, and kidneys, with mutations linked to human congenital defects including anencephaly, spina bifida, cleft lip and palate, and ventricular septal defects. Genome-wide association studies implicate Shroom3 in human conditions such as chronic kidney disease and heterotaxy. While this suggests that Shroom3 expression continues postnatally, the extent of adult expression patterns remain unexplored. To address this, we first harvested organs from adult mice heterozygous for a LacZ reporter inserted into the Shroom3 allele (Shroom3

Indexed as

Gene Expression Regulation, DevelopmentalMicrofilament ProteinsAnimalsMiceMice, Inbred C57BLMicrofilament ProteinsShrm protein, mouseGene expressionImmunofluorescenceLacZ reporter geneProtein expressionShroom3

Identifiers

PMID41101717
PMCPMC13564383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.