Evidence map›Paper›PMID 41101705›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2026

Number of Alpha Peaks in the Electroencephalogram Is Associated With Clinical Phenotype and Copy Number Variants in Youths With Autism.

Vardan Arutiunian, Morgan Opdahl, Catherine A W Sullivan, Megha Santhosh, Emily Neuhaus, Heather Borland, Raphael A Bernier, Susan Y Bookheimer, Mirella Dapretto, Allison Jack and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Vardan ArutiunianCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington.
Morgan OpdahlCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington.
Catherine A W SullivanDepartment of Pediatrics, Yale School of Medicine, Yale University, New Haven, Connecticut.
Megha SanthoshCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington.
Emily NeuhausCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington; Department of Psychiatry and Behavioral Science, University of Washington, Seattle, Washington; Institute on Human Development and Disability, University of Washington, Seattle, Washington.
Heather BorlandCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington.
Raphael A BernierDepartment of Psychiatry and Behavioral Science, University of Washington, Seattle, Washington.
Susan Y BookheimerCenter for Autism Research and Treatment, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Mirella DaprettoCenter for Autism Research and Treatment, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Allison JackDepartment of Psychology, George Mason University, Fairfax, Virginia.
Shafali JesteDepartment of Pediatrics and Neurology, University of Southern California Keck School of Medicine, Children's Hospital of Los Angeles, Los Angeles, California.
James C McPartlandYale Child Study Center, Yale School of Medicine, Yale University, New Haven, Connecticut.
Adam NaplesYale Child Study Center, Yale School of Medicine, Yale University, New Haven, Connecticut.
John D Van HornSchool of Data Science, University of Virginia, Charlottesville, Virgina; Department of Psychology, University of Virginia, Charlottesville, Virginia.
Kevin A PelphreyDepartment of Neurology, School of Medicine, University of Virginia, Charlottesville, Virginia.
Sara Jane WebbCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington; Department of Psychiatry and Behavioral Science, University of Washington, Seattle, Washington; Institute on Human Development and Disability, University of Washington, Seattle, Washington. Electronic address: sara.webb@seattlechildrens.org.
Abha R GuptaDepartment of Pediatrics, Yale School of Medicine, Yale University, New Haven, Connecticut; Yale Child Study Center, Yale School of Medicine, Yale University, New Haven, Connecticut; Department of Neuroscience, Yale School of Medicine, Yale University, New Haven, Connecticut.

Funding

Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
Subnetwork-based Quantitative Imaging Biomarkers for Therapy Assessment in AutismR01NS035193 · NINDS · YALE UNIVERSITY · PI JAMES S DUNCAN, LAWRENCE H. STAIB · 1996 to 2026
$9.2M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI DOHERTY, DANIEL · 2014 to 2019
$7.9M
Parsing ASD Heterogeneity: Neuroendophenotypes of Social Attention and Sensory ResponsivityR01MH117982 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAPRETTO, MIRELLA, PELPHREY, KEVIN A · 2018 to 2023
$3.8M
NICHD NIH HHS P50 HD103524NICHD NIH HHS U54 HD083091NIMH NIH HHS R01 MH100028NIMH NIH HHS R01 MH117982NINDS NIH HHS R01 NS035193
6 · The paper itself

Abstract

backgroundElectroencephalography (EEG) alpha-band neural activity has previously been reported to be altered in autism spectrum disorder (ASD), but no studies have addressed different parameters of alpha-band activity and their relationship to clinical phenotype and copy number variants (CNVs) in ASD.

methodsThe study included 310 youths with and without ASD and consisted of resting-state EEG, behavioral phenotyping, and genome-wide CNV analysis.

resultsFirst, the results revealed that alpha peak power was reduced in ASD, and younger-age autistic males had a higher number of peaks compared with younger-age autistic females. Second, a higher number of alpha peaks was related to lower language skills and a higher presence of autistic traits. Finally, a higher number of alpha peaks was related to a higher number of CNVs.

conclusionsIn this study, we explored a novel measure (number of peaks) associated with both clinical phenotype and genetic burden and provide evidence that supports alterations in alpha-band activity in ASD.

Indexed as

Alpha RhythmAutism Spectrum DisorderDNA Copy Number VariationsAdolescentChildElectroencephalographyFemaleHumansMalePhenotypeAlpha-band EEG activity in autismAperiodic-adjusted alpha powerClinical phenotypeCopy number variationExcitation/inhibition imbalanceNumber of peaksThalamocortical activity

Identifiers

PMID41101705
PMCPMC12959347

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.