Evidence map›Paper›PMID 41101535›Full record

Observational studyClinical nutrition ESPEN2025

Maternal metabolic dysfunction-associated steatotic liver disease during pregnancy and its impact on offspring steatosis.

Corie M Klepper, Andrew T Trout, Shun Dong, Lin Fei, Traci E Stankiewicz, Jennifer Wayland, Maria E Moreno-Fernandez, Senad Divanovic, Stavra A Xanthakos, Emily DeFranco and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical nutrition ESPEN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Corie M KlepperDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Andrew T TroutDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Shun DongDepartment of Mathematics, University of Cincinnati, Cincinnati, OH, USA.
Lin FeiDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Traci E StankiewiczDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jennifer WaylandDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Maria E Moreno-FernandezDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Senad DivanovicDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Stavra A XanthakosDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Emily DeFrancoDepartment of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jessica G WooDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Marialena MouzakiDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: marialena.mouzaki@cchmc.org.

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE ARMISTEAD DENSON · 2007 to 2026
$24.4M
Immunopathogenesis of Non-alcoholic Fatty Liver DiseaseR01DK099222 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Senad Divanovic · 2013 to 2026
$5.6M
NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK099222
6 · The paper itself

Abstract

BACKGROUND &

aimTo investigate the yet unexplored links between maternal and offspring outcomes of pregnancy metabolic dysfunction-associated steatotic liver disease (MASLD).

methodsProspective observational study using magnetic resonance imaging with proton density fat fraction (MRI-PDFF) to determine the presence of maternal and offspring liver steatosis during gestation (3rd trimester) and in the first year postpartum. Women were deemed at high or low risk for MASLD if they had risk factors (pre-pregnancy obesity or MASLD, gestational diabetes, rapid weight gain during pregnancy). Multivariable regression and longitudinal mixed models assessed associations and changes in MRI-derived fat measures.

resultsWe recruited 57 pregnant women; 47 (82 %) were high-risk for MASLD. MASLD was seen in 18 % (n = 10) of women (and 15 % [n = 7/47] of those high-risk), with a median PDFF of 5.9 % (IQR: 5.6-12.0 %). Maternal weight, BMI and HDL-C differed between groups. The fetal liver and placental PDFF of offspring of women with and without MASLD were not different. N = 7 (12 %) infants had clinically significant steatosis in utero, all offspring of mothers without gestational MASLD. Of the 30 mothers with repeat liver MRI-PDFF at 9 months postpartum, ten (33 %)had MASLD. N = 44 infants followed up at either 3 or 9 months of age, with only one still demonstrating significant steatosis 9 months. No infant exposed to gestational MASLD had significant steatosis in the first year.

conclusionsGestational MASLD is generally mild, but hepatic fat fraction increases postpartum. Clinically significant hepatic steatosis occurs as early as in utero but is not associated with maternal MASLD.

Indexed as

Fatty LiverPregnancy ComplicationsPrenatal Exposure Delayed EffectsAdultBody Mass IndexDiabetes, GestationalFemaleHumansInfant, NewbornLiverMagnetic Resonance ImagingPregnancyProspective StudiesRisk FactorsGestational diabetesMASLDPre-pregnancy obesitySteatosis

Identifiers

PMID41101535
PMCPMC13344880

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.