Evidence map›Paper›PMID 41101453›Full record

Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2025

Incremental diagnostic value of artificial intelligence-derived coronary artery calcium in

Orit Barrett, Aakash Shanbhag, Ryan Zaid, Robert J H Miller, Mark Lemley, Valerie Builoff, Joanna X Liang, Paul B Kavanagh, Christopher Buckley, Damini Dey and 2 more

Abstract readClinical Trial, Phase III
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Evaluation of Myocardial Blood Flow UsingCurrent cardiology reports · 2026
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Orit BarrettDepartments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Aakash ShanbhagDepartments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences Cedars-Sinai Medical Center, Los Angeles, CA, USA; Signal and Image Processing Institute, Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, USA.
Ryan ZaidDepartments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Robert J H MillerDepartment of Cardiac Sciences, University of Calgary, Calgary, AB, Canada.
Mark LemleyDepartments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Valerie BuiloffDepartments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Joanna X LiangDepartments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Paul B KavanaghDepartments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Christopher BuckleyGE Healthcare, Pollards Wood, Buckinghamshire, HP8 4SP, United Kingdom.
Damini DeyDepartments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Daniel S BermanDepartments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Piotr J SlomkaDepartments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Piotr.Slomka@cshs.org.

Funding

Patient-specific Outcome Prediction from Cardiovascular Multimodality Imaging by Artificial IntelligenceR35HL161195 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Piotr J Slomka · 2022 to 2026
$5.0M
Integrating Artificial Intelligence for Optimal Analysis of CardiacPET/CTR01EB034586 · NIBIB · CEDARS-SINAI MEDICAL CENTER · PI DI CARLI, MARCELO F, SLOMKA, PIOTR J · 2022 to 2025
$2.9M
NHLBI NIH HHS R35 HL161195NIBIB NIH HHS R01 EB034586
6 · The paper itself

Abstract

backgroundPositron emission tomography (PET) myocardial perfusion imaging (MPI) is a powerful tool for predicting coronary artery disease (CAD). Coronary artery calcium (CAC) provides incremental risk stratification to PET-MPI and enhances diagnostic accuracy. We assessed the additive value of the CAC score, derived from PET/CT attenuation maps to stress total perfusion deficit (TPD) results using the novel

methodsPatients from the

resultsAmong 498 patients (72% males, median age 63 years) 30.1% had CAD. Incorporating the CAC score resulted in a greater AUC with manual scoring (AUC = .87, 95% confidence interval [CI]: .34-.90; P = .015) and AI-based scoring (AUC = .88, 95% CI: .85-.90; P = .002) compared to stress TPD alone (AUC = .84, 95% CI: .80-.92).

conclusionsCombining automatically derived TPD and CAC score enhances

Indexed as

Artificial IntelligenceCalciumCoronary Artery DiseaseCoronary VesselsMyocardial Perfusion ImagingPositron Emission Tomography Computed TomographyPyridazinesAgedCoronary AngiographyFemaleHumansMaleMiddle AgedSensitivity and SpecificityBMS 747158-02CalciumPyridazines(18)F-flurpiridazArtificial intelligenceAttenuation corrected coronary artery calciumDeep learningPET perfusion

Identifiers

PMID41101453
PMCPMC13016407

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.