Noninvasive longitudinal assessment of early-stage Duchenne muscular dystrophy: In vivo diaphragm imaging in mdx mice.

Jeehyun Lee, Nia O Myrie, Woojin M Han, Young C Jang, Andrés J García, Stanislav Emelianov

Abstract read

In one paragraph

Article in Ultrasonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jeehyun LeeSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: jeehyun.lee@gatech.edu.

Nia O MyrieWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA. Electronic address: nmyrie@gatech.edu.

Woojin M HanDepartment of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: woojin.han@mssm.edu.

Young C JangDepartment of Orthopedics, Emory Musculoskeletal Institute, Emory School of Medicine, Atlanta, GA, USA. Electronic address: young.jang@emory.edu.

Andrés J GarcíaGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: andres.garcia@me.gatech.edu.

Stanislav EmelianovSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA. Electronic address: stas@gatech.edu.

Funding

Damage Modeling and Vascular Imaging Correlation with Implant Induced Skin NecrosisR01AR082523 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI STANISLAV Y EMELIANOV, Scott J Hollister · 2024 to 2026

$1.6M

NIAMS NIH HHS R01 AR082523

6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration, with respiratory muscle weakness significantly impacting patient outcomes. Early detection of disease progression is critical for evaluating treatment strategies. This study investigates the feasibility of ultrasound shear wave elasticity imaging (US-SWEI) for assessing early-stage respiratory muscle changes in mdx mice, a model for DMD, aged 3 to 6 months. Longitudinal in vivo imaging evaluated the diaphragm's viscoelastic properties, with group and phase velocities measured to capture biomechanical changes. In mdx mice, group velocity increased from 3.47±0.15to4.20±0.20m/s, whereas wild-type values changed only modestly (2.76±0.11to3.01±0.16m/s). Histological analysis confirmed a significant positive correlation between group velocity and collagen deposition (R

Indexed as

DiaphragmElasticity Imaging TechniquesMuscular Dystrophy, DuchenneAnimalsDisease Models, AnimalFeasibility StudiesMaleMiceMice, Inbred C57BLMice, Inbred mdxDiaphragmDMDElastographyMuscular dystrophyPhase velocityShear wave elasticity imagingViscoelastic

Identifiers

PMID41100905

DOI10.1016/j.ultras.2025.107846

PMCPMC13280731

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.