Evidence map›Paper›PMID 41100846›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Can vigorous physical activity mitigate the effect of systemic inflammation on cognitive performance? Results from a large older community dwelling population in The Netherlands.

Anne Fink, Constantin Reinke, Benjamin Aretz, Michael T Heneka, Gabriele Doblhammer

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anne FinkGerman Center for Neurodegenerative Diseases, Bonn, Germany.ORCID 0000-0003-2106-2940
Constantin ReinkeInstitute of Sociology and Demography, University of Rostock, Rostock, Germany.ORCID 0000-0003-3228-1794
Benjamin AretzInstitute of Sociology and Demography, University of Rostock, Rostock, Germany.ORCID 0000-0003-0143-0873
Michael T HenekaLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg.ORCID 0000-0003-4996-1630
Gabriele DoblhammerGerman Center for Neurodegenerative Diseases, Bonn, Germany.ORCID 0000-0001-7746-0652

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundElevated systemic inflammation is associated with poorer cognitive function, while vigorous physical activity enhances cognition.ObjectiveThis study examines whether physical activity moderates the relationship between systemic inflammation and cognitive performance.MethodsWe analyzed 24,661 adults (50+) from the Dutch Lifelines cohort across two waves. Cognitive performance was assessed via a validated composite score from the Cogstate Brief Battery, with higher scores indicating lower cognitive performance. Leukocyte count (3-11 × 10

Indexed as

CognitionCognitive DysfunctionExerciseInflammationAgedAged, 80 and overAging in PlaceCohort StudiesFemaleHumansIndependent LivingMaleMiddle AgedNetherlandsNeuropsychological TestsAlzheimer's diseasecognitive performancecohort studyphysical activitysystemic inflammation

Identifiers

PMID41100846
PMCPMC12647380

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.