ReviewTissue barriers2026
Structural and functional insights of the podocyte slit diaphragm complex.
Review in Tissue barriers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Beyond the structure-function paradigm: A comprehensive review of intrinsically disordered proteins.Biochemistry and biophysics reports · 2026Review
- Inhibiting the P2X7R-NLRP3 inflammasome pathway regulates CXCL16 to alleviate podocyte injury in mice with adriamycin nephropathy.Scientific reports · 2026Article
- Common Carp Kidney as a Multipurpose Biomarker Organ: Insights from Perfluorooctanoic Acid Exposure.Toxics · 2026Article
- A natural nephroprotective adjuvant for cancer chemotherapy: Rosmarinic acid disrupts IL-17 A-Ferroptosis coupling in Ifosfamide-induced renal injury.Medical oncology (Northwood, London, England) · 2026Article
- Molecular Survival Strategies Against Kidney Filtration: Implications for Therapeutic Protein Engineering.Biophysica · 2026Article
- Advances in Biomimetic Cell Membrane Nanoplatforms for Renal-Targeted Theranostics: From Pathophysiological Basis to Membrane-Stratified Design.International journal of nanomedicine · 2026Review
- Emerging genetic mechanisms of glomerular proteinuria: a podocyte-centered multi-layer network perspective.Frontiers in genetics · 2026Review
- Clinical evaluation of rituximab combined with ACE inhibitors and statins in refractory nephrotic syndrome: associations with proteinuria, lipid profiles, and podocyte-related biomarkers.Frontiers in pharmacology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glomerular podocytes, specialized epithelial cells, are central to the filtration function of vertebrate kidneys. Through their interdigitating foot processes, podocytes provide epithelial coverage to capillaries. They maintain selective filtration by allowing water, ions, and small solutes to filter while retaining proteins and larger molecules in the blood. The slit diaphragm (SD), a specialized junction between podocyte foot processes, along with glomerular basement membrane (GBM) and fenestrated endothelium, serves as a glomerular filtration barrier (GFB). Injury to GFB, such as loss of SD integrity and foot process effacement, compromises permselectivity and results in proteinuria. The SD consists of junctional proteins (nephrin, Neph1), adaptors (podocin, CD2AP), and channels (e.g. TRPC6), which assemble into a molecular sieve and a dynamic signaling hub. Monogenic mutations and resultant structural defects in SD components perturb podocyte filtration function, leading to proteinuria, nephrotic syndrome, and focal segmental glomerulosclerosis. This review summarizes structural and functional insights into SD architecture and emphasizes advances from biochemical, biophysical, and high-resolution imaging approaches. We particularly discuss the role of intrinsically disordered regions in mediating oligomerization and protein - protein networks within the SD. Emerging Cryo-EM studies further provide new perspectives on the stoichiometry of Nephrin - Neph1 complexes and their implications for SD ultrastructure. Finally, we outline unresolved questions regarding SD composition, assembly, and signaling, proposing how integrative structural biology may illuminate mechanisms underlying proteinuric kidney diseases.
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Registered trials
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