Evidence map›Paper›PMID 41100768›Full record

ArticleThe Journal of physiology2025

Angiotensin-converting enzyme 2 regulates the placental response to repeated hypoxia-reoxygenation insult.

India A Brooker, Jessie M Sutherland, Saije K Endacott, Eugenie R Lumbers, Joshua J Fisher, Kirsty G Pringle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

India A BrookerSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan (Awabakal Country), NSW, Australia.ORCID 0000-0002-0245-9582
Jessie M SutherlandSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan (Awabakal Country), NSW, Australia.ORCID 0000-0001-9672-2371
Saije K EndacottSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan (Awabakal Country), NSW, Australia.ORCID 0000-0001-8974-5575
Eugenie R LumbersSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan (Awabakal Country), NSW, Australia.ORCID 0000-0003-3945-3923
Joshua J FisherSchool of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan (Awabakal Country), NSW, Australia.ORCID 0000-0002-0505-0598
Kirsty G PringleSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan (Awabakal Country), NSW, Australia.ORCID 0000-0002-6770-0496

Funding

Australian Government Research Training Program StipendAustralian Research Council Discovery Early Career Researcher Award DE220100006John Hunter Hospital Charitable Trust Grant G2400510
6 · The paper itself

Abstract

Fetal growth restriction is linked to placental oxidative stress owing to defective placentation and hypoxia-reoxygenation (H/R). Angiotensin-converting enzyme 2 (ACE2), a key regulator of oxidative stress, is reduced in placentae of fetuses with growth restriction. We aimed to develop a physiologically relevant model of repeated H/R to determine the protective role of ACE2 during repeated H/R insult. Human term placental explants (n = 8 per group) were cultured for 24 h in normoxia (8% O

Indexed as

HypoxiaOxygenPeptidyl-Dipeptidase APlacentaAngiotensin-Converting Enzyme 2FemaleHeme Oxygenase-1HumansNADPH Oxidase 4NADPH OxidasesNF-E2-Related Factor 2Oxidative StressPregnancyACE2 protein, humanAngiotensin-Converting Enzyme 2Heme Oxygenase-1NADPH Oxidase 4NADPH OxidasesNF-E2-Related Factor 2OxygenPeptidyl-Dipeptidase Aangiotensin‐converting enzyme 2fetal growth restrictionhypoxia/reoxygenationoxidative stressplacentarenin–angiotensin system

Identifiers

PMID41100768
PMCPMC12645529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.