ArticleProceedings of the National Academy of Sciences of the United States of America2025
Linking the production of reactive oxygen species to the expression of antimicrobial peptides through aquaporin in an arthropod.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In arthropods, bacterial infection activates dual oxidase 2 (Duox2) to produce extracellular reactive oxygen species (ROS), while stimulating the expression of antimicrobial peptides (AMPs) through immune deficiency (Imd)/Relish pathway. Although both strategies contribute significantly to antibacterial immunity, the Duox2/ROS system and Relish/AMPs pathway are generally considered separate branches. In the present study, we report that these two branches are connected by an aquaporin 4 (Aqp4) in a crustacean, the red swamp crayfish
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