Trial reportPloS one2025
Efficacy of 8-week oral iron supplementation on fatigue and physical capacity in young women with iron deficiency anemia: An uncontrolled pilot clinical trial.
Trial report in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Music-integrated strength-proprioceptive training improves lower-limb performance and postural balance in adolescents with visual impairment: a randomized controlled trial.Scientific reports · 2026Trial
- Effects of Tabata training combined with iron supplementation on proprioceptive acuity in young women with iron deficiency anemia: a randomized controlled trial.BMC sports science, medicine & rehabilitation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to investigate the effect of 8 weeks of ferrous sulfate supplementation (160 mg elemental iron/day) on fatigue and physical performance in young women with iron deficiency anemia (IDA). In this uncontrolled pilot clinical trial, twenty-three women with IDA aged between 18 and 30 years participated in this study. Aerobic fitness, muscle strength and muscle endurance were performed to evaluate physical capacities. Moreover, the multidimensional fatigue inventory (MFI-20) was used to assess general, physical, and mental fatigue, reduced activity and motivation. Due to multiple comparisons, the level of significance was set at 0.00625. The results of this study revealed that muscle endurance values increased significantly (P < 0.001) after 8 weeks of iron supplementation compared to pre-intervention values. In addition, scores of general (P < 0.001), physical (P < 0.001) and mental (P < 0.001) fatigue, and reduced activity (P < 0.001) and motivation (P = 0.006) decreased significantly in post- intervention compared to pre- intervention. However, there were no improvements in aerobic fitness (P = 0.008) and muscle strength (P = 0.086). In women of reproductive age with IDA, 8 weeks of iron supplementation improve muscle endurance, but not aerobic fitness or muscle strength. These improvements could be explained by the increase in hemoglobin (Hb) (by 17.62%) and serum ferritin (by 63.2%) concentrations and the decrease in fatigue scores after the supplementation period.
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