ArticlePloS one2025
Trends and disparities in dilated cardiomyopathy related mortality among adults in the United States: A CDC WONDER analysis (1999-2023).
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 2 papers.
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2 citing papers in PubMed.
- Article
- Temporal trends in mortality involving atrial fibrillation and rheumatic heart disease: a 25-year nationwide analysis.Frontiers in cardiovascular medicine · 2025Article
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16 authors.
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Abstract
backgroundDilated cardiomyopathy (DCM) is a progressive myocardial disease characterized by ventricular dilation and impaired systolic function, often leading to heart failure and increased mortality. This study aims to analyze DCM-related mortality trends among adults in the United States from 1999 to 2023.
methodsTrends in DCM-related mortality among adults aged ≥ 25 years from 1999 to 2023 were analyzed using the CDC WONDER multiple-cause of death database. Age adjusted mortality rates (AAMRs) per 100,000 persons and annual percent change (APC) were calculated and stratified by year, sex, race, census region and urbanization status.
resultsFrom 1999 to 2023, there were 184,073 deaths in the United States attributed to DCM. Over this period, the AAMR declined from 5.19 in 1999 to 2.34 in 2023. Between 1999 and 2002, the AAMR decreased significantly from 5.19 to 4.38 (APC -6.20* [95% CI, -12.42 to -0.72; P = 0.0208]). The trend remained stable between 2002 and 2005, followed by a significant decline between 2005 and 2014, where the AAMR decreased from 4.96 to 2.66 (APC -6.84* [95% CI, -9.00 to -3.05; P = 0.0300]). The trend then remained relatively unchanged from 2014 to 2023. In 2023, males (3.4) averaged a considerably higher AAMR than females (1.38). Among racial groups, the highest AAMR in 2023 was reported in the Non-Hispanic (NH) Black group (3.77), followed by the NH White group (2.3), the Hispanics and Latinos (1.67) and the NH Others group (NH Asians and NH Native American Indian or Alaskan Native) at 1.23. Overall from 1999 to 2020, rural areas (3.52) averaged a significantly higher AAMR than urban areas (3.50). Regionally, in 2023, the Western region averaged the highest AAMR at 2.69, followed by the South at 2.31, the Midwest at 2.42 and lastly the Northeast at 1.83.
conclusionOur analysis revealed a significant decline in DCM-related mortality rates in the United States from 1999 to 2023, with the most substantial reductions occurring between 1999 and 2014. However, disparities persist, with higher mortality rates observed in males, NH Black individuals, and rural populations. Regional variations also highlight the need for targeted interventions to further reduce the burden of DCM.
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