ArticlePloS one2025
Nonlinear association between TyG-BMI and MAFLD: A cross-sectional study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Relationship between triglyceride-glucose-derived obesity indices and NAFLD in adolescents: A cross-sectional study.Medicine · 2026Article
- Body Mass Index Outperforms Triglyceride-Glucose Index in Predicting MAFLD in Type 2 Diabetes: A Cross-Sectional Mediation and Interaction Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- The development and evaluation of nine non-conventional lipid parameters for metabolic dysfunction-associated fatty liver disease in Chinese medical health examination adults: a single-center retrospective study.Frontiers in nutrition · 2026Article
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6 authors.
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Abstract
backgroundThe relationship between the triglyceride glucose-body mass index (TyG-BMI) and the incidence of metabolic associated fatty liver disease (MAFLD) is a trending research area. This association is highly important in the realms of healthcare and public health.
objectiveTo explore the impact of TyG-BMI on MAFLD and its contribution to the evolution of diverse phenotypes of fatty liver.
methodsIn this cross-sectional study, curve fitting was used to assess the relationships between TyG-BMI and MAFLD as well as different MAFLD phenotypes, and multivariate ordinal logistic regression methods were employed to explore the stability of these relationships.
resultsCurve fitting revealed a nonlinear relationship between TyG-BMI and MAFLD, with a critical threshold of approximately 176.78. Similar relationships were observed between TyG-BMI and different fatty liver phenotypes. Multivariate logistic regression revealed that the TyG-BMI was independently associated with different fatty liver phenotypes (nonfibrotic MAFLD odds ratio (OR) = 11.29; 95% confidence interval (CI) = 8.38-15.21, p < 0.001; fibrotic MAFLD OR = 37.24, 95% CI = 25.92-53.51, P < 0.001). Even after full variable adjustment, this relationship remained stable (nonfibrotic MAFLD OR = 5.99, 95% CI = 3.25--11.06, P < 0.001; fibrotic MAFLD OR = 5.24, 95% CI = 2.28--12.06, P < 0.001). Correlation analysis revealed a positive correlation between TyG-BMI and CAP (correlation coefficient, 0.60) and a weak positive correlation with SWE (correlation coefficient, 0.29).
conclusionsThe TyG-BMI manifests a nonlinear relationship with the risk of developing distinct MAFLD phenotypes, suggesting its utility as a pivotal metric in the formulation of screening and preventive strategies for MAFLD.
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