Evidence map›Paper›PMID 41100456›Full record

Trial reportPloS one2025

TB will never end because of us: Experiences of TB preventive treatment among people living with HIV/AIDS in South Africa.

Lebohang M Mlambo, Matshepo Setlaleleng, Kate Shearer, Nombuyiselo J Mofokeng, Phineas Ndou, Minja Milovanovic, Laura Steiner, Leisha Genade, Limakatso Lebina, Neil A Martinson and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lebohang M MlamboPerinatal HIV Research Unit (PHRU), University of the Witwatersrand, South Africa.ORCID https://orcid.org/0000-0001-7998-9242
Matshepo SetlalelengPerinatal HIV Research Unit (PHRU), University of the Witwatersrand, South Africa.
Kate ShearerJohns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America.ORCID https://orcid.org/0000-0003-2049-4258
Nombuyiselo J MofokengPerinatal HIV Research Unit (PHRU), University of the Witwatersrand, South Africa.
Phineas NdouPerinatal HIV Research Unit (PHRU), University of the Witwatersrand, South Africa.
Minja MilovanovicPerinatal HIV Research Unit (PHRU), University of the Witwatersrand, South Africa.
Laura SteinerJohns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America.
Leisha GenadePerinatal HIV Research Unit (PHRU), University of the Witwatersrand, South Africa.
Limakatso LebinaAfrica Health Research Institute, Clinical Trials Unit, KwaZulu-Natal, South Africa.ORCID https://orcid.org/0000-0001-6825-0573
Neil A MartinsonPerinatal HIV Research Unit (PHRU), University of the Witwatersrand, South Africa.
Christopher J HoffmannJohns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America.
Jill OwczarzakDepartment of Health, Johns Hopkins Bloomberg School of Public Health, Behavior, and Society, Baltimore, Maryland, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis (TB) remains a major global health challenge, particularly for people living with HIV/AIDS (PLWHA). TB preventive treatment (TPT) has been found to reduce the risk of TB among PLWHA. As TPT has become a standard component of HIV care, understanding client-level perceptions and knowledge of TPT is crucial to optimizing uptake.

methodsThis qualitative sub-study was conducted within a cluster-randomized trial evaluating a TPT initiation strategy in two provinces of South Africa. The qualitative component explored patient understanding and experiences with HIV, TB, and TPT through in-depth interviews. PLWHA receiving care at participating public-sector healthcare facilities in the North West and Free State provinces were systematically purposively selected. Thematic analysis was used to identify themes.

resultsThirty-three adult PLWHA were interviewed. Most participants understood TB, household transmission risk, and that PLWHA are more susceptible to TB. Participants were aware TB is curable and associated its risk and transmission to dirty environments, neglecting flu-like symptoms and lifestyle habits (alcohol use and smoking). Participants highlighted that health-seeking behaviors, treatment adherence, and community perception influence TB burden, stressing TB prevention and treatment as community challenges. Knowledge of TPT varied, with most participants emphasizing the need for clients to take initiative in their treatment. Participants requested that healthcare workers provide more details about TPT through posters and pamphlets in clinics, and suggested community engagement to encourage uptake. While adherence was acknowledged, concerns included side effects and the burden of taking both antiretroviral therapy and TPT.

conclusionIndividual and community social and health-related factors, along with acceptability of TPT, might affect uptake and retention. While TPT was seen as important, concerns about side effects and dual treatment burdens highlight the need for improved education and support. Strengthening healthcare communication, expanding TPT information, and promoting TPT as a proactive health decision may motivate uptake.

Indexed as

Acquired Immunodeficiency SyndromeHIV InfectionsTuberculosisAdultAntitubercular AgentsFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedSouth AfricaAntitubercular Agents

Identifiers

PMID41100456
PMCPMC12530581

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.